Growth-factor-receptor-binding protein 2 (GRB2) is a non-enzymatic adaptor protein that plays a pivotal role in precisely regulated signaling cascades from cell surface receptors to cellular …

GRB2, or Growth Factor Receptor-Bound Protein 2, is a pivotal adaptor protein in intracellular signal transduction pathways, particularly within receptor tyrosine kinase (RTK) signaling …

Clearance effect of fucoidan in serum, heart, kidney, lung and liver was found due to organic and inorganic compounds reduced SOS1, CREB, GSK3b, and GRB2 protein level were changed …

2018年11月3日 · In this study, the protein expression levels of SOS1, GSK3β, GRB2, CREB and IRS1 in aging mice were ameliorated with fucoidan and fucoxanthin. There were also …

1997年11月1日 · In PC12 cells, neurotrophins transactivate cyclic AMP response element-binding protein (CREB) by inducing its phosphorylation on a critical residue (Ser-133) that enables …

Grb2能够同时与Shc、Sos结合形成Shc-Grb2-Sos复合物,并将Sos激活，激活的Sos与质膜上的Ras蛋白结合，并将其激活,引起 信号级联反应。 Grb2蛋白含有一个 SH2结构域 和两个SH3 …

2023年8月30日 · HIV-1 Pol is identified to have a physical interaction with growth factor receptor-bound protein 2 (GRB2) in human HEK293 and/or Jurkat cell lines by using affinity tagging …

2019年1月21日 · Treatment with fucoidan and fucoxanthin reduced the expression levels of SOS1 and GRB2 while increasing GSK3β, CREB and IRS1 proteins expression in the aging process. …

In this paper, analysis of cortical tissue from Ras-GRF knockout mice shows that p140 GRF1 and p130 Ras-GRF2 are the predominant mediators of NMDAR activation of the Ras/Erk signaling …

2020年1月23日 · We propose that nSH3/cSH3 binding peptides, which effectively interrupt Grb2–SOS1 association, can serve as tumor suppressors. The Grb2–SOS1 mechanism …