Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction / cell communication. In humans, the GRB2 protein is encoded by the …

Growth Factor Receptor-bound protein 2 (Grb2) is a key molecule in intracellular signal transduction, linking activated cell surface receptors to downstream targets by binding to …

2018年2月8日 · In this review, we have compiled the maximum tumor conformations caused by the involvement of the Grb2, the central role of Grb2 in numerous oncogenic pathways and …

GRB2, or Growth Factor Receptor-Bound Protein 2, is a pivotal adaptor protein in intracellular signal transduction pathways, particularly within receptor tyrosine kinase (RTK) signaling …

2 天之前 · The unbound Grb2-SH2 domain showed fewer and more stable clusters in comparison with Grb2-SH2 domain-drug complexes. Compound DO71_2 showed fewer clusters in …

2011年1月1日 · Development of Grb2 Inhibitors as Anticancer Drugs. The recognition that Grb2 is important in several oncogenic signaling pathways is the origin of several efforts to selectively …

2005年12月1日 · 生长因子受体结合2（Grb2）是一种普遍表达的衔接蛋白，可在细胞表面生长因子受体与Ras信号通路之间提供关键的联系。因此，它与几种重要的人类恶性肿瘤的发生有关 …

1999年10月8日 · CGP78850 is a potent competitor of Grb2 SH2-phosphopeptide interactions. This inhibitor has been obtained by rational drug design and is specific toward the Grb2 SH2 …

Grb2 signaling is critical for cell cycle progression and actin-based cell motility, and, consequently, more complex processes such as epithelial morphogenesis, angiogenesis and …

2024年3月31日 · grb2是响应外界生长因子信号后介导ras/mapk信号通路的经典接头蛋白，在细胞质和细胞核中均有表达，但其在细胞核内的功能及其相关机理尚未完全明晰。