SUMOylation of Grb2 enhances the ERK activity by increasing ... - PubMed
2014年4月29日 · Knockdown of Grb2 reduced the ERK activity and suppressed cell motility and tumorigenesis in vitro and in vivo, which were all rescued by stable ectopic re-expression of …
经典且复杂的细胞信号通路：RAS/RAF/MEK/ERK - 知乎
这些磷酸化的位点可以招募包含SH2（Src Homology 2）结构域的信号分子，如生长因子受体结合蛋白 Grb2。 Grb2 进而招募鸟苷酸交换因子 SOS蛋白，进而激活鸟苷酸交换因子（Guanine - …
FCRL1 regulates BCR-induced ERK activation through GRB2
A GRB2/SHIP-1 signaling module has the capacity to negatively regulate ERK activation through a variety of mechanisms. The inositol phosphatase activity of SHIP-1 may function to reduce …
ERK 通路 | Cell Signaling Technology
由不同的刺激物激活的级联反应的特定组分差异较大，但通路的结构通常包含一组对接蛋白（Shc、GRB2、Crk 等），它们将受体连接到一个鸟苷酸交换因子上（SOS、C3G 等），信 …
Grb2 and GRAP connect the B cell antigen receptor to Erk MAP …
2018年3月9日 · Here, we investigated the role of Grb2 and GRAP in human B cells and found that both adaptor proteins can amplify Ca 2+ mobilization and activation of the Erk MAP kinase …
SUMOylation of Grb2 enhances the ERK activity by increasing its …
Grb2 SUMOylation at K 56 facilitates the formation of Grb2-Sos1 complex via recruiting more Sos1, leading to the ERK activation and consequently promoting cell migration and …
GRB2在将胰岛素受体与Ras信号通路联系起来中的作用,Science - X …
1993年6月25日 · 胰岛素主要通过增加鸟嘌呤核苷酸释放活性的速率来激活 Ras。在这里，我们显示胰岛素诱导的 ERK 激活通过生长因子受体结合蛋白 2 (GRB2) 的稳定过表达而增强，但不 …
Synergistic anticancer effect of Grb2 and ITGA1 on cancer cells …
2019年1月1日 · The preponderance of evidence continues to indicate that Grb2 has a critical role in mitogen activated protein kinase (MAPK) signaling. Grb2 activates Ras/ERK signaling and …
Grb2 的 SUMO 化通过增加其与 Sos1 的结合来增强 ERK 活性。
2014年4月30日 · 为了测试 erk 活性和细胞转化，小鼠成纤维细胞系nih/3t3和小鼠结肠癌细胞系cmt-93用于grb2敲低、异位再表达、细胞转化和迁移等实验。 免疫沉淀 (IP) 用于寻找与 SUMO …
SOS Phosphorylation and Disassociation of the Grb2-SOS …
1996年3月15日 · In this article, we have demonstrated that the ERK pathway is specifically responsible for the feedback phosphorylation of SOS and disassociation of the Grb2-SOS …
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