2015年10月29日 · Here, we demonstrate that in two independent Theileria -transformed macrophage cell lines Grb2 expression is down-regulated concomitant with loss of tumor …

Furthermore, GRB2 also plays a crucial role in linking RTK to phosphatidylinositol-3-kinase (PI3K)/serine protein kinase AKT (PI3K/AKT) signaling . The c-SH3 of GRB2 can …

2012年11月6日 · Lastly, Grb2 associates with Gab1, another adaptor protein, which participates in the phosphoinositide 3-kinase (PI3K)–Akt pathway (Fig. 1D). Grb2 preferentially uses its N …

Binding of adaptor molecules, such as growth factor receptor-bound protein 2 (Grb2) and phosphoinositide 3-kinase (PI3K), to the cytoplasmic region of CD28 is critical for T-cell …

2024年12月5日 · Our results suggest that DUS4L is a key regulator of LUAD progression and metastasis through its interaction with GRB2 and subsequent modulation of the PI3K/AKT and …

2022年12月15日 · Binding of adaptor molecules, such as growth factor receptor-bound protein 2 (Grb2) and phosphoinositide 3-kinase (PI3K), to the cytoplasmic region of CD28 is critical for T …

2021年10月11日 · High-throughput RNA-sequencing analysis revealed that inhibition of Hey1 results in decreased GRB2 expression in melanoma cells. Last, functional experiments …

目的:探讨生长因子受体结合蛋白2 (GRB2)基因沉默介导磷脂酰肌醇3-激酶 (PI3K)/蛋白激酶B (AKT)/核因子κB (NF-κB)信号通路对动脉粥样硬化 (AS)大鼠脂质沉积和炎性浸润的调控机制. …

We report that inhibition of PI3K by wortmannin or an inhibitory p85 construct, p85deltaiSH2, reduced the TCR-induced Syk-dependent activation of Erk2, as well as the appearance of …

Limited research has focused on the role of dihydrouridine synthases (DUS) family members in human tumors. Our previous findings indicated an impact of dihydrouridine synthase 4 like …