2024年12月25日 · GRIN2C (Glutamate Ionotropic Receptor NMDA Type Subunit 2C) is a Protein Coding gene. Diseases associated with GRIN2C include Alzheimer's Disease and Retinitis Pigmentosa 30. Among its related pathways are Unblocking of NMDA receptors, glutamate binding and activation and Transmission across Chemical Synapses.

Glutamate [NMDA] receptor subunit epsilon-3 is a protein that in humans is encoded by the GRIN2C gene. [5][6] N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors.

Positions in the N-methyl-D-aspartate Receptor GluN2C Subunit M3 and M4 Domains Regulate Alcohol Sensitivity and Receptor Kinetics. Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is …

该受体是由不同亚基组成的四聚体（通常是亚基1与亚基2A-D中的一个或多个亚基的异源二聚体），形成一个对钙、钾和钠具有通透性的通道，其性质由亚基组成决定。 受体亚基组成的改变与帕金森病、阿尔茨海默病、抑郁症和精神分裂症等病理生理状况相关。 可选剪接导致多个转录变异体。 [RefSeq，2013年6月提供] Dir./Indir. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

2024年10月28日 · Clinical resource with information about GRIN2C, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2025年1月14日 · We identified a rare missense variant in GRIN2C associated with late-onset autosomal dominant Alzheimer's disease. These findings highlight the role of GluN2C-containing NMDARs in glutamatergic signaling and their potential contribution to AD pathogenesis.

RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.

2025年2月18日 · 此次研究首次报道了一个与晚发常染色体显性遗传AD相关的 GRIN2C 罕见错义变异。 这些发现强调了含GluN2C的NMDA受体在谷氨酸能信号传导中的作用及其对AD发病机制的潜在贡献。 此变异可能通过影响14-3-3蛋白与GluN2C之间的相互作用，进而影响NMDA受体的表面表达和功能，最终导致AD的发生。 谷氨酸是 中枢神经 系统的主要兴奋性神经递质，在大脑的各种功能中扮演着重要角色，尤其是在皮层和海马区域。 NMDA受体介导的兴奋性信号传递对 …

Title: Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility. Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is …

与人类的GRIN2C（NMDA型谷氨酸离子型受体2C亚型）正同源。 [由基因组资源联盟，2022年4月提供] Genome sequence of the Brown Norway rat yields insights into mammalian evolution. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gene and alternative splicing annotation with AIR.