G protein-coupled receptor kinase 4 (GRK4) is an enzyme that is encoded by the GRK4 gene in humans. [5]This gene encodes a member of the G protein-coupled receptor kinase subfamily …

2024年12月25日 · GRK4 (G Protein-Coupled Receptor Kinase 4) is a Protein Coding gene. Diseases associated with GRK4 include Hypertension and Hypertension, Essential. Among its …

GRK4 genetic polymorphism plays an important role in the regulation of hypertension. Mutations in GRK4 gene is associated with stress fracture. Buffalo colostrum beta-lactoglobulin inhibits …

2021年4月7日 · Aims: G protein-coupled receptor kinase 4 (GRK4) has been reported to play an important role in hypertension, but little is known about its role in cardiomyocytes and …

2008年3月17日 · GRK4 is the only GRK in which 4 splice variants (GRK4α, β, γ, and δ) have been identified in humans. 8,19,20 GRK4α, the full-length isoform, is most homologous with …

The primary role of GRK4 is to phosphorylate G protein-coupled receptors (GPCR), which leads to desensitization of the G protein signaling mechanism while simultaneously recruiting β …

G protein-coupled receptor kinases (GRKs) are important regulatory proteins for many G protein-coupled receptors, but little is known about GRK4 pharmacogenetics. We hypothesized that 3 …

GRK4 gene variants in humans (GRK4 A>65L, A>142V, and A>486V) are associated with Hypertension in several but not all ethnic groups. GRK4 gene variants impair the function of …

1997年4月11日 · G protein-coupled receptor kinase 4 (GRK4) presents some peculiar characteristics that make it a unique member within the GRK multigene family. For example, …

G protein-coupled receptor kinases (GRKs) are important regulatory proteins for many G protein-coupled receptors, but little is known about GRK4 pharmacogenetics. We hypothesized three …