2024年12月25日 · GRK6 (G Protein-Coupled Receptor Kinase 6) is a Protein Coding gene. Diseases associated with GRK6 include Whim Syndrome 1 and Huntington Disease. Among its related pathways are GPCR downstream signalling …

GRK6 is widely and relatively evenly expressed throughout the body, but with particularly high expression in immune cells. [6] GRK6 exists in three splice variants that differ in the carboxyl terminal region that regulates membrane association: one form is palmitoylated , another contains a lipid-binding polybasic domain, and the third is ...

In this review, we compile important findings concerning GRK6 regulation for a better pathophysiological understanding of the intracellular interaction in the context of inflammation and show clinical implications—for example, the identification of possible therapy goals in the treatment of chronic inflammatory hyperalgesia.

GRK6 is potential marker for organ injury and survival after cardiopulmonary bypass; the crystalline GRK6 RGS homology domain forms an extensive dimer interface using conserved hydrophobic residues distinct from those in GRK2 that bind Galpha(q) potential role of endogenous GRK6 in the regulation of M(3) mACh receptor

2021年2月18日 · Background: G protein-coupled receptor kinase 6 (GRK6) is part of the G protein-coupled receptor kinase family, whose members act as key regulators of seven-transmembrane receptor signalling. GRK6 seems to play a role in regulation of inflammatory processes, but mechanisms of transcriptional regulation of GRK6 expression in inflammatory cell ...

2016年11月24日 · In this study, we demonstrate that GRK6 regulates of self-renewal and lymphoid differentiation of HSCs, and underscore its underlying importance in the maintenance of reactive oxygen species...

2010年8月20日 · The analysis presents the structure of the G protein‐coupled receptor (GPCR) kinase 6 (GRK6) in an active conformation. A model of the GRK–GPCR complex is provided and this combined with mutational...

Human G-protein coupled receptor kinase 6 (GRK6) belongs to the GRK4 kinase subfamily of the G protein-coupled receptor kinase family which comprises of GRK1, GRK2, and GRK4. These kinases phosphorylate ligand-activated G-protein coupled receptors (GPCRs), driving heterotrimeric G protein coupling, …

2024年1月7日 · Title: Hypermethylation of the G protein-coupled receptor kinase 6 (GRK6) promoter inhibits binding of C/EBPα, and GRK6 knockdown promotes cell migration and invasion in lung adenocarcinoma cells. GRK6 overexpression can significantly enhance tumor proliferation and invasion, which was consistent with clinical findings.

GRK6 is a protein that plays a significant role in the regulation and desensitization of G protein-coupled receptors (GPCRs) in the brain, particularly in dopaminergic areas. It is primarily localized to synaptic membranes and can translocate to the …