2015年9月16日 · Here we identify gasdermin D (Gsdmd) by genome-wide clustered regularly interspaced palindromic repeat (CRISPR)-Cas9 nuclease screens of caspase-11- and caspase-1-mediated pyroptosis in mouse...

2023年6月5日 · GSDMD forms membrane pores that can promote cytolysis and the release of interleukin-1 family cytokines into the extracellular space. Recent discoveries have revealed biochemical and cell...

2015年11月27日 · Here we report that gasdermin D (GSDMD) is another crucial component of inflammasomes. We discovered the presence of GSDMD protein in nigericin-induced NLRP3 inflammasomes by a quantitative...

2024年12月25日 · GSDMD (Gasdermin D) is a Protein Coding gene. Diseases associated with GSDMD include Muckle-Wells Syndrome and Familial Cold Autoinflammatory Syndrome. Among its related pathways are Innate Immune System and Inflammasomes. An important paralog of this gene is GSDMA.

Gasdermin D (GSDMD) serves as a key executor to trigger pyroptosis and is emerging as an attractive checkpoint in host defense, inflammatory, autoimmune diseases, and many other systemic diseases.

2018年3月13日 · GSDMD controls neutrophil death and negatively regulates neutrophil-mediated innate immunity. Thus, GSDMD can exert context-dependent proinflammatory and anti-inflammatory effects and is a unique target for antibacterial and anti-inflammatory therapies.

23 小时之前 · Pyroptosis is a regulated form of inflammatory cell death in which Gasdermin D (GSDMD) plays a central role as the key effector molecule. GSDMD-mediated pyroptosis is characterized by complex biological features and considerable heterogeneity in its expression, mechanisms, and functional outcomes across various tissues, cell types, and pathological …

2025年2月10日 · Gsdmd deficiency led to severe abscess formation, extensive skin damage, bacterial spread, and cellular inflammation in a mouse model of S. aureus skin infection . The activation of GSDMD-dependent pyroptosis and IL-18 secretion has been shown to improve antitumor immunity by maintaining healthy gut microbiota (71, 75, 76).

GSDMD, a key pyroptosis-executing protein, is linked to inflammatory signal transduction, activation of various inflammasomes, and the release of downstream inflammatory cytokines. Thus, inhibiting GSDMD activation is considered an effective strategy for treating related inflammatory diseases.

2025年2月8日 · Gasdermin D (GSDMD) ontrols the release of the proinflammatory cytokines and pyroptotic cell death [Review]. The GSDMD promotes IL-1 release from hyperactive or pyroptotic cells, with a specific focus on defining how these distinct cell fates associated with GSDMD activity can be regulated.