2020年1月30日 · The pathway of AIM2 inflammasome-mediated pyroptosis, the AIM2/Caspase-1/GSDMD pathway, was explored after experimental SAH in vivo and in primary cortical …

2018年12月15日 · The DNA sensor absent in melanoma 2 (AIM2) forms an inflammasome complex with ASC and caspase-1 in response to Francisella tularensis subspecies novicida …

2024年2月7日 · In our study, we have identified NU6300 as a specific GSDMD inhibitor that covalently interacts with cysteine-191 of GSDMD, effectively blocking its cleavage while not …

结果发现，在电转和etoposide诱导细胞DNA损伤中Aim2−/−、Ice−/−和Gsdmd−/−神经元的死亡数目均低于wt（fig3 a, b），说明AIM2炎症小体通路涉及细胞DNA损伤相关死亡过程。对脑发育 …

2024年7月21日 · In GSDMD deficient mice, the accumulation of DNA damage activated more receptor AIM2 inflammasomes (Figure S4A,C, Supporting Information), accompanied by a …

GSDMD promotes pyroptosis by mediating the activation of inflammasomes such as NLRP3, AIM2, and TLR4, thereby exacerbating kidney damage and impairing renal function. APOL1 …

2020年1月30日 · Pyroptosis-associated proteins mediated by the AIM2 inflammasome were significantly increased in vivo and in vitro following experimentally induced SAH. After AIM2 …

2018年12月12日 · Recent studies have identified gasdermin D (GSDMD) as the molecule executing pyroptosis by forming pores on plasma membrane following activation by …

2022年6月23日 · Proximity-induced caspase-1 activation triggers the maturation of interleukin (IL)-1β/IL-18 and the cleavage of gasdermin D (GSDMD), providing inflammation and …

2024年3月1日 · We further demonstrated that GSDMD-mediated pyroptosis induced inflammation via the nuclear factor kB (NF-κB)/absent in melanoma-2 (AIM-2)/caspase-1 pathway. In …