2024年12月25日 · GUCY1A2 (Guanylate Cyclase 1 Soluble Subunit Alpha 2) is a Protein Coding gene. Diseases associated with GUCY1A2 include Nemaline Myopathy 5A. Among its related pathways are Sweet Taste Signaling and Cardiac conduction. Gene Ontology (GO) annotations related to this gene include GTP binding and phosphorus-oxygen lyase activity.

Guanylate cyclase soluble subunit alpha-2 is an enzyme that in humans is encoded by the GUCY1A2 gene. [5] [6]

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the Guanylate Cyclase enzyme, which is activated by nitric oxide.

GUCY1A2 is a prognostic marker in Kidney renal clear cell carcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.

2022年12月12日 · GUCY1A1 and GUCY1B1, genes encoding sGC, are expressed at high levels in platelets and vascular smooth muscle cells. In humans, carriers of the CAD risk variant rs7692387 have reduced sGC α 1...

2021年5月25日 · Results: We found that GUCY1A2 was highly expressed in GC tissues compared to adjacent noncancerous tissues (P < 0.001). qRT-PCR (P < 0.001) and meta-analysis (SMD = 0.65, 95% CI: 0.20-1.10) confirmed the difference in GUCY1A2 expression.

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide.

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide.

什么是GUCY1A2基因？ GUCY1A2基因，也叫做guanylate cyclase 1 soluble subunit alpha 2，是一个位于11号染色体q22.3位置的基因。这个基因编码的是一种蛋白质，属于可溶性鸟苷酸环化酶（Soluble guanylate cyclases，简称sGC）家族。在生物学上，GUCY1A2通常被称为GC-SA2。

Molecular cloning and expression of a new alpha-subunit of soluble guanylyl cyclase. Interchangeability of the alpha-subunits of the enzyme. The consensus coding sequences of human breast and colorectal cancers.