2024年9月30日 · Guggul is the gum resin found in various plants native to South Asia. It has several potential benefits, such as helping to manage acne and hypothyroidism. However, …

Guggul is made from the oily sap (gum resin) of the guggul tree (Commiphora wightii). The guggul tree grows in India, Bangladesh, and Pakistan. Guggul contains plant steroids that might affect...

Guggulipid is an ethyl acetate extract of resin known as guggul from the tree Commiphora wightii / mukul (Arn.) Bhandari. Chemical analysis revealed that the compounds responsible for the major activities of gum guggul are the isomers E- and Z-guggulsterone.

2003年8月13日 · Recently, guggulsterones, the purported bioactive compounds of guggul, have been shown to be potent antagonists of 2 nuclear hormone receptors involved in cholesterol metabolism, establishing a plausible mechanism of action for the hypolipidemic effects of …

Today guggul gum resin is used for arthritis, lowering high cholesterol, “hardening of the arteries” (atherosclerosis), acne and other skin diseases, and weight loss. How does work? Guggul contains substances that lower cholesterol and triglycerides. One of these substances also decreases the redness and swelling that occurs in some types of acne.

Gugulipid is a natural health product that is principally used to reduce elevated blood cholesterol levels, in the prevention of cardiovascular disease. It has been used for many years as a hypocholesterolemic agent in India, where it is has received prescription drug status, due to its high level of efficacy as determined by clinical trials.

2022年1月5日 · Guggul is a resin extract that has been used in Ayurvedic medicine for centuries. Although animal studies suggest it can reduce cholesterol levels, results from human studies are mixed.

Gugulipid administration was associated with histological abnormalities in liver, increased alanine aminotransferase levels, lower hepatic SR-BI content, hypercholesterolemia due to increased HDL cholesterol levels, endothelial dysfunction, enhanced atherosclerosis, and accelerated death in animals with severe ischemic heart disease.

Studies in both animal models and humans have shown that this resin, termed gum guggul, can decrease elevated lipid levels. The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin.

OBJECTIVE: To evaluate the scientific evidence on guggul for hyperlipidemia including expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing.