GABA is located throughout the GI tract and is found in enteric nerves as well as in endocrine-like cells, implicating GABA as both a neurotransmitter and an endocrine mediator influencing GI function. GABA mediates its effects via GABA receptors which are either ionotropic GABA A or metabotropic GABA B. The latter which respond to the agonist ...

Association of gut microbiota and GABA in mental health and brain function. It has been well-accepted that dysbiosis of the gut microbiota is strongly linked to human health, including...

The gut microbiota has a clear impact on neurotransmitters including serotonin, dopamine, GABA, and glutamate. Mental disorders such as schizophrenia, depression, anxiety disorders, and autism spectrum disorder are associated with gut microbiota.

GABA effects in the GI tract depend on the activation of ionotropic GABAA and GABAC receptors and metabotropic GABAB receptors, resulting in a potential noteworthy regulation of both the excitatory and inhibitory signalling in the ENS.

Genome-based metabolic modelling of the human gut microbiota revealed multiple genera with the predicted capability to produce or consume GABA. A transcriptome analysis of human stool samples from healthy individuals showed that GABA-producing pathways are actively expressed by Bacteroides, Parabacteroides and Escherichia species.