NCG-MHC-dKO小鼠模型作为一种新的实验工具，展示了在缓解人源PBMC异体移植GvHD、保持IgG抗体半衰期以及研究CD3T细胞功能及抗体药物方面的潜力。 该模型为GvHD的研究提供了新的途径，并为免疫治疗策略的发展提供了重要的支持。 进一步的研究和应用将进一步揭示该模型的潜力和临床价值。 参考文献： [1]Pearson T, et al. (2008). Specificity and effector mechanisms of human neutrophil defensins in antimicrobial immunity. Blood, 111 (1): 8-15. [2]Shultz LD, et al. …

In this Perspective, we provide an overview of available mouse models of acute and chronic GvHD, discuss their uses and limitations, and provide guidance on selecting an appropriate model. We also briefly discuss the graft-versus-leukemia (GVL) effect, although readers are referred to other recent reviews for more detail on this topic ...

2019年9月26日 · Aiming for a higher translational value, we constructed an MHC major mismatched [C57BL/6 (H-2 Kb) to BALB/c (H-2Kd)] aGVHD mouse model based on busulfan/cyclophosphomide (BU–CY) conditioning and...

人源pbmc移植的m-nsg和m-nsg-b2m小鼠适合需要成熟t细胞功能的短期体内实验，包括hiv感染，肿瘤免疫和gvhd等研究。

Charles River offers allogeneic and xenogeneic preclinical Graft vs Host Disease (GVHD) mouse models. The GvHD model can be used to model the disease side effect of hematopoietic stem cell transplantation, or can be used as a screening model for drugs that are immunostimulating.

小鼠模型是研究GvHD的病理生理学和了解导致GvHD发展关键机制的一个重要临床前工具，GvHD进展机制和治疗方法的发展主要来自同种异体小鼠模型，然而并不能很好的转化到临床中；GvHD的人源化小鼠模型，将人类外周血单个核细胞（hPBMCs）注射到 免疫缺陷小鼠 中 ...

2023年6月26日 · NCG-MHC-dKO小鼠模型作为一种新的实验工具，展示了在缓解人源PBMC异体移植GvHD、保持IgG抗体半衰期以及研究CD3T细胞功能及抗体药物方面的潜力。 该模型为GvHD的研究提供了新的途径，并为免疫治疗策略的发展提供了重要的支持。 进一步的研究和应用将进一步揭示该模型的潜力和临床价值。 参考文献： [1]Pearson T, et al. (2008). Specificity and effector mechanisms of human neutrophil defensins in antimicrobial immunity. Blood, 111 (1): …

The NCG mouse model from Charles River is triple immunodeficient and lack mature T, B, and NK cells, making this an ideal model to study immuno-oncology, infectious disease, graft-versus-host disease (GvHD), and tissue transplant studies.

In this Perspective, we provide an overview of currently available mouse models of acute and chronic GvHD, highlighting their benefits and limitations, and discuss research and clinical opportunities for the future.

2022年1月1日 · GVHD can be classified as acute (aGVHD) or chronic (cGVHD). Each form involves different phenotypes of alloreactive T cells, with CD8 + cells binding to antigens presented on the surface of major histocompatibility complex (MHC) class I and CD4 + cells recognizing cognate antigens bound to MHC class II (Zeiser & Blazar, 2017).