颗粒酶A（Granzyme A，GzmA）是一种丝氨酸蛋白酶，主要定位于活化淋巴细胞和自然杀伤（NK）细胞的胞质中。 它是细胞毒性颗粒中表达丰度最高的蛋白酶之一，具有多种重要的生物学功能。

Granzyme A (GzmA, EC 3.4.21.78, CTLA3, HuTPS, T-cell associated protease 1, cytotoxic T lymphocyte serine protease, TSP-1, T-cell derived serine proteinase) is a tryptase [5] [6] [7] and is one of the five granzymes encoded in the human genome.

2024年12月25日 · GZMA (Granzyme A) is a Protein Coding gene. Diseases associated with GZMA include Shigellosis and Smallpox. Among its related pathways are IL-9 Signaling Pathways and IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types.

Granzyme A是CTL和NK细胞中较为丰富的蛋白酶。 它通过穿孔素进入到靶细胞，进而诱导caspase非依赖性的细胞死亡。 被赖氨酰肽链内切酶激活后，Granzyme A就会裂解硫酯底物。 人Granzyme A作为一个前体 (262个残基)被合成，这个前体带有一个信号肽 (残基1-26)、一个前肽 (残基27-28)和一条成熟链 (残基29-262)。 纯化的重组人Granzyme A由残基26-262组成。 知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以 …

2020年5月2日 · 人们对颗粒酶的研究已有30多年了，主要的关注点是两个大量存在的成员（gzma和gzmb）及其在杀死癌细胞中的作用。 GZMB被认为通过切割caspase-3或caspase ...

2020年5月29日 · Killing results from the cleavage of GSDMB by lymphocyte-derived granzyme A (GZMA), which unleashes its pore-forming activity. Interferon-γ (IFN-γ) up-regulates GSDMB expression and promotes pyroptosis. GSDMB is highly expressed in certain tissues, particularly digestive tract epithelia, including derived tumors. Introducing GZMA-cleavable ...

此处描述的蛋白质是一种 T 细胞和自然杀伤细胞特异性丝氨酸蛋白酶，可作为细胞毒性 T 淋巴细胞和自然杀伤细胞裂解靶细胞所必需的常见成分。 [RefSeq 提供，2008 年 7 月] Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells.

2020年4月16日 · GZMA from cytotoxic lymphocytes cleaves and activates GSDMB to induce target cell pyroptosis. This immune effector mechanism promotes CTL-mediated tumor clearance in mice. High GSDMB expression in the digestive system suggests the importance of GSDMB-mediated immunity in these tissues and will guide immunotherapy for related cancers.

Santiago et al. show that extracellular granzyme A (GzmA) contributes to gut inflammation and colorectal cancer (CRC) development by promoting IL-6 production in macrophages. Therapeutic inhibition of GzmA attenuates inflammation and CRC development, suggesting that GzmA could be useful to treat gut inflammation and prevent CRC.

2023年3月10日 · Purpose: Granzyme A (GZMA) is a potential prognostic target for various cancer types. However, its therapeutic significance in breast cancer with immune infiltration remains controversial. We analyzed GZMA expression and its prognostic value in breast cancer with immune cell infiltration.