1994年10月7日 · In vivo administration of hemoglobin has resulted in significant toxicity, due in part to contamination with bacterial endotoxin (lipopolysaccharide (LPS)). To better …

1994年10月7日 · In vivo administration of hemoglobin has resulted in significant toxicity, due in part to contamination with bacterial endotoxin (lipopolysaccharide (LPS)). To better …

Hemoglobin (Hb) functions as a frontline defense molecule during infection by hemolytic microbes. Binding to LPS induces structural changes in cell-free Hb, which activates the redox …

2012年1月1日 · Hb 肽的 LPS 结合特性通过 Hb 亚基的突变分析得到证实。 在第 56 位引入赖氨酸至天冬氨酸突变，Hbα 中的第 60 和 61 位，Hbβ 中的第 59、66 和 95 位。 突变导致 Hb-α 和 …

2012年1月31日 · Here, we mapped LPS-binding sites on Hb using a systematic approach of computational predictions and empirical validations. Surface plasmon resonance (SPR) …

在本研究中，通过分析200-650 nm波长范围内Hb的吸收光谱和圆二色性光谱，研究了LPS对天然人HbA0和共价交联Hb（alpha alpha Hb）结构的影响。 将oxyHb与几种LPS一起孵育会导 …

Hemoglobin, a newly recognized lipopolysaccharide (LPS)-binding protein that enhances LPS biological activity. Cell-free hemoglobin (Hb) is a purified preparation of human hemoglobinthat …

1994年10月7日 · Test the hypothesis that Hb enhances the LPS-induced procoagulant activity of human umbilical vein endothelial cells (HUVEC) by increasing LPS binding to the cells and …

2011年10月28日 · Hemoglobin (Hb) functions as a frontline defense molecule during infection by hemolytic microbes. Binding to LPS induces structural changes in cell-free Hb, which activates …

脂多糖（Lipopolysaccharide, LPS）是革兰氏阴性细菌外膜的主要成分之一，由类脂A、核心多糖和O-抗原三部分组成，其中O-抗原决定了LPS的血清型，具有重要的生物学功能和作用机制。