Triple-stranded DNA (also known as H-DNA or Triplex-DNA) is a DNA structure in which three oligonucleotides wind around each other and form a triple helix. In triple-stranded DNA, the third strand binds to a B-form DNA (via Watson–Crick base-pairing) double helix by forming Hoogsteen base pairs or reversed Hoogsteen hydrogen bonds.

H-DNA又称铰链DNA，是三螺旋结构中较为特殊的一种，1987年由Mirkin等在一种持粒的酸性溶液中首次发现。 H-DNA 可在任何以镜象重复的 寡聚核苷酸 中产生（核苷酸序列具有H回文结构）。 H-DNA的形成始于共聚物内部突环，其中的双链在一边轻微旋转，折叠回去，以生成第一个三股碱基对。 这种成核过程建立了一种非平衡的H-DNA构型。 缠绕与变性导致了其余 DNA 分子负超螺旋松弛。 3′和5′一半的多聚嘧啶链都可以作H-DNA的给予体链，而形成两种异构体，它们在构型 …

H-DNA plays important roles in vivo and is inherently mutagenic and recombinogenic, such that elements of the H-DNA structure may be pharmacologically exploitable. In this review we discuss the biological consequences and therapeutic potential of triple helical DNA structures.

如何理解h-dna这种三螺旋结构的模式？ 突发奇想，如果一种生物的基因是H-DNA这种三螺旋结构的，那么从携带的信息量，族群繁衍生殖等方面会出现哪些可以推测想象出来的结果？

2024年12月5日 · H-DNA is an intramolecular DNA triplex formed by homopurine/homopyrimidine mirror repeats. Since its discovery, the field has advanced from characterizing the structure in vitro to discovering its existence and role in vivo. H-DNA interacts with cellular machinery in unique ways, stalling DNA and RNA polymerases and causing genome instability.

2024年12月5日 · H-DNA is an intramolecular DNA triplex formed by homopurine/homopyrimidine mirror repeats. Since its discovery, the field has advanced from characterizing the structure in vitro to discovering its existence and role in vivo. H-DNA interacts with cellular machinery in unique ways, stalling DNA and RNA polymerases and causing genome instability.

The term H DNA was coined in 1985 by Victor Lyamichev, Maxim Frank- Kamenetskii and myself (1). Our work was inspired by numerous studies showing that many regulatory regions of eukaryotic genes, both in chromatin and in the cloned state, exhibited hypersensitivity...

2025年3月4日 · Ribosomal DNA arrays are the genomic element with a 40.94-fold H-DNA enrichment. Across acrocentric chromosomes, we report that 54.82% of H-DNA motifs found in these chromosomes are in rDNA array loci. We discover that binding sites for the PRDM9-B allele, a variant of the PRDM9 protein, are enriched for H-DNA motifs.

2009年9月28日 · H-DNA又称铰链DNA，是三螺旋结构中较为特殊的一种，1987年由Mirkin等在一种持粒的酸性溶液中首次发现。 H-DNA可在任何以镜象重复的寡聚核苷酸中产生（核苷酸序列具有H回文结构）。

H-DNA又称铰链DNA，是三螺旋结构中较为特殊的一种，1987年由Mirkin等在一种持粒的酸性溶液中首次发现。H-DNA可在任何以镜象重复的寡聚核苷酸中产生（核苷酸序列具有H回文结构）。