Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

2015年4月1日 · In this review, we discuss the actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases. 1. Introduction. Hepatocyte growth factor (HGF), also called scatter factor, is a polypeptide growth factor that belongs to the plasminogen family.

2023年1月19日 · Here, we report that hepatocyte growth factor (HGF) signaling plays an important role in promoting normal and damaged liver CD8 + T cell Fas-mediated apoptosis through its only receptor,...

肝细胞生长因子 (HGF)，也是分散因子 (SF)，是一种旁分泌细胞生长、运动和形态形成因子。 它由间充质细胞和靶细胞分泌，主要作用于上皮细胞和内皮细胞，但也作用于造血祖细胞和 T 细胞。 它已被证明在胚胎器官发育中，特别是在肌肉形成中，在成人器官再生和伤口愈合中具有重要作用。 [1]. Lin XY, et al. [Role of Hepatocyte Growth Factor in Wound Repair]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2018 Dec 20;40 (6):822-826. Chinese. [Content Brief] MCE 生物医学词典 …

Under normal conditions, hepatocyte growth factor (HGF)-induced activation of its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand delivery, ligand activation at the target cell surface, and ligand activated receptor internalization and degradation.

该基因编码的蛋白质与肝细胞生长因子受体结合，可调节多种细胞和组织类型的细胞生长、细胞运动和形态发生。 可变剪接导致多个转录本变体，其中至少一个编码前原蛋白，该前原蛋白经过蛋白水解加工产生 alpha 和 beta 链，形成成熟的异二聚体。 该蛋白由间充质细胞分泌，在主要为上皮来源的细胞上充当多功能细胞因子。 这种蛋白质还在血管生成、肿瘤发生和组织再生中发挥作用。 虽然编码的蛋白质是丝氨酸蛋白酶肽酶 S1 家族的成员，但它缺乏肽酶活性。 该基因的突变与 …

肝细胞生长因子 (HGF，又称 Scatter Factor) 是一类具有血管生成能力的因子。 HGF最初被发现为上皮细胞的成纤维细胞源性细胞动力因子。 它由间充质细胞、成纤维细胞和平滑肌细胞合成。 活性 HGF 是一种由重链 (α链，62 kDa) 和轻链 (β链，32-36 kDa) 组成的异质二聚体，它们通过二硫键连接在一起。 HGF 通过与 c-Met 受体结合来发挥其生物学功能 (例如增殖/分化/存活/运动发生)。 HGF/c-Met 信号轴以旁分泌的方式参与上皮器官的发育，发挥上皮的再生作用，并促进许 …

Transforming growth factor-beta (TGF- β) and hepatocyte growth factor (HGF) are inflammatory cytokines which function as key regulators of immunological homeostasis and inflammatory responses. They have been linked to inflammatory bowel diseases (IBD).

2024年12月10日 · Hepatocyte growth factor regulates the development of highly pure cultured chief cells from rat stomach by stimulating chief cell proliferation in vitro.

2018年1月1日 · In 1984, hepatocyte growth factor (HGF) was first reported as a potent mitogen of rat hepatocytes in a primary culture. The primary structure of HGF became evident with cDNA cloning in 1989, and HGF was simultaneously identified as a novel growth factor (Nakamura et al. 1989; Miyazawa et al. 1989).