The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic amine histamine. It is expressed …

Histamine H 1 receptor (H 1 R) is a GPCR involved in type I hypersensitivity allergic reactions resulting from various allergens [91]. H 1 R is expressed in various tissues throughout the …

2024年1月2日 · Histamine receptors are a group of G protein-coupled receptors (GPCRs) that play important roles in various physiological and pathophysiological conditions. Antihistamines …

Histamine and its receptors (H1R–H4R) play a crucial and significant role in the development of various allergic diseases. Mast cells are multifunctional bone marrow-derived tissue-dwelling …

2024年12月25日 · HRH1 (Histamine Receptor H1) is a Protein Coding gene. Diseases associated with HRH1 include Allergic Rhinitis and Chronic Urticaria. Among its related pathways are …

Histamine H 1 receptor (H1R) is one of the targets of histamine in the nervous system and the peripheral tissues. Protein kinase Cδ (PKCδ) signaling is involved in histamine-induced …

2021年4月7日 · Here, we present the cryo-electron microscopy (cryo-EM) structure of the human H1R in complex with a Gq protein in an active conformation via a NanoBiT tethering strategy.

是一种属于视紫红质样G蛋白偶联受体家族的受体，可被 组胺 激活。 它在平滑肌、血管内皮细胞、心脏、中枢神经系统中表达。 H1受体与细胞内G 蛋白的 Gαq亚基 （英 …

2025年1月4日 · H1R; H1-R; HH1R; hisH1 Summary Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various …

2024年1月15日 · Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine …

The histamine 1 receptor (H1R) is widely distributed in various body tissues, including the endothelium, immune cells, and smooth muscle, and plays a crucial role in regulating …

Histamine-activated histamine H 1 receptor (H1R) signaling regulates many gene expressions, mainly through the protein kinase C (PKC)/extracellular signal-regulated kinases (ERK) …

2025年1月4日 · H1R, which is widely distributed in the body in epithelial cells and smooth vascular, neuronal, glial and immune cells, can cause allergic and inflammatory symptoms …

2024年7月10日 · Our results suggest that H1R in MS cholinergic neurons is critical for contextual fear retrieval, and could be a potential therapeutic target for individuals with fear-related …

Histamine H1 type receptor (H1R) is a major subtype of histamine membrane receptors family, which has displayed diverse biological functions in various tissues and cells. In the current …

We analysed HR expression in human gastrointestinal tissue specimens by quantitative reverse transcription‐polymerase chain reaction and immunostaining. We found that H1R, H2R, and …

2015年12月1日 · The histamine (HA) receptor subtype 1 (H1R) and H4R are expressed on immune cells and contribute to an inflammatory reaction. Both receptor subtypes individually …

2011年6月22日 · Histamine H 1 receptor (H 1 R) antagonists are very effective drugs alleviating the symptoms of allergic reactions. Here we show the crystal structure of the H 1 R complex …

2021年10月1日 · Histamine-activated histamine H 1 receptor (H1R) signaling regulates many gene expressions, mainly through the protein kinase C (PKC)/extracellular signal-regulated …

2021年2月18日 · Our results suggest that the H 1 R deficiency in BF cholinergic neurons is critical for sensorimotor gating deficit, social impairments and anhedonia-like behavior. This finding …