Histones H2AX and H3 are part of the nucleosome, proteins directly surrounding the DNA, providing a biological context of high relevance for toxicity endpoints characterizing …

2020年4月1日 · We quantitatively examined the responses for γH2AX and pH3 by benchmark dose analyzing (BMD) using PROAST software. We found that the three toxins increased both …

2021年12月1日 · H2AX histones is a variant of histone H2A in mammalian cells which possess a specific Ser-Gln motif in its C-terminal end. PI3 kinases phosphorylate H2AX histones as a key …

Recently, a new strategy for genotoxicity screening, based on the combined analysis of phosphorylated histones H2AX (γH2AX) and H3 (pH3), was proposed to discriminate …

2020年8月17日 · Reported here is the first comprehensive characterization of distinct orchestration and dynamic processes on cellular γ-H2AX and p-H3 for two major types of …

最近，提出了一种基于磷酸化组蛋白 H2AX (γH2AX) 和 H3 (pH3) 的联合分析的遗传毒性筛选新策略，以有效区分非胚胎和致裂化合物。 然而，γH2AX 生物标志物也可以通过细胞凋亡诱导。 …

2019年7月9日 · Notably, the γH2AX assay performs well (91% predictivity) and efficiently differentiates aneugenic and clastogenic compounds when coupled with the pH3 biomarker. …

Notably, the γH2AX assay performs well (91% predictivity) and efficiently differentiates aneugenic and clastogenic compounds when coupled with the pH3 biomarker. Currently, no formal …

碧云天生产的DNA损伤检测试剂盒(γ-H2AX免疫荧光法)，英文名为DNA Damage Assay Kit by γ-H2AX Immunofluorescence，是通过免疫荧光染色检测DNA损伤标记物γ-H2AX (即磷酸化 …

The gH2AX/pH3 method has the unique possibility to provide mechanistic insights into the mechanism of genotoxicity by combining two relevant endpoints in a single assay. gH2AX/pH3 …