2020年2月19日 · Here, by using forward genetic screens based on Ca 2+ imaging, we isolated hydrogen-peroxide-induced Ca2+ increases (hpca) mutants in Arabidopsis, and identified HPCA1 as a leucine-rich-repeat...

1996年2月23日 · The mitogen-activated protein kinase (MAPK) family is comprised of key regulatory proteins that control the cellular response to both proliferation and stress signals. In this study we investigated the factors controlling MAPK activation by H2O2 and explored the impact of altering the pathways to ki …

2000年10月10日 · Fluctuations in H 2 O 2 levels can affect the intracellular activity of key signaling components including protein kinases and protein phosphatases. Rhee et al. discuss recent findings on the role of H 2 O 2 in signal transduction. Specifically, H 2 O 2 appears to oxidize active site cysteines in phosphatases, thereby inactivating them.

1996年2月23日 · The mitogen-activated protein kinase (MAPK) family is comprised of key regulatory proteins that control the cellular response to both proliferation and stress signals. In this study we investigated the factors controlling MAPK activation by H 2 O 2 and explored the impact of altering the pathways to kinase activation on cell survival following ...

2023年5月1日 · Here we show that OsRbohB is the main NADPH oxidase involved in ABA-induced H 2 O 2 production and ABA-mediated physiological responses. OsDMI3 directly interacts with and phosphorylates OsRbohB at Ser-191, which is OsDMI3-mediated site-specific phosphorylation in ABA signaling.

2001年9月14日 · Interestingly, a specific tyrosine kinase inhibitor, genistein, further stimulated the H 2 O 2-induced AMPK activity by 70% without altering the AMP:ATP. Taken together, our results suggest that AMP:ATP ratio is the major parameter to which AMPK responds under the oxidative stress, but AMPK may be regulated in part by a tyrosine kinase ...

2018年10月19日 · Reactive oxygen species (ROS), in particular H 2 O 2, regulate intracellular signaling through reversible oxidation of reactive protein thiols present in a number of kinases and phosphatases. H 2 O 2 has been shown to regulate mitogen-activated protein kinase (MAPK) signaling depending on the cellular context.

Hydrogen peroxide (H2O2) has emerged as an important intracellular signaling molecule and has been shown to stimulate the growth of vascular smooth muscle cells. Activation of p44 and p42 extracellular signal-regulated protein kinases (ERK1 and ERK2) is an important step in the cascade leading to ce …

1995年7月1日 · In the present study, we demonstrate that (1) O 2− but not H 2 O 2 stimulates activation of MAP kinase, (2) the activation by O 2− is PKC dependent, and (3) the differential activation of MAP kinase is not well explained by greater induction of …

2023年2月9日 · H 2 O 2, acting as an intracellular messenger, activates phosphatidylinositol-3 kinase (PI3K) and its downstream target Akt, and promotes cell survival. The aim of the current study was to understand the mechanism by which PI3K/Akt signaling promotes survival in SH-SY5Y neuroblastoma cells.