TPPU protects tau from H2O2-induced hyperphosphorylation in HEK293/tau ...
The present study investigated the role of a sEH inhibitor, 1-(1-propanoylpiperidin-4-yl)-3-[4-(trifluoromethoxy)phenyl] urea (TPPU), on H 2 O 2-induced tau phosphorylation and the …
Spatially-resolved intracellular sensing of hydrogen peroxide …
2015年11月20日 · We demonstrate the use of the HyPer-Tau sensor for three applications; dose-dependent response of human cells to exogenous hydrogen peroxide, a model immune …
Hydrogen peroxide induces transient dephosphorylation of tau …
2001年9月28日 · In this study, we tested the effects of oxidative stress induced by a brief exposure to hydrogen peroxide (H 2 O 2) on the phosphorylation state of the tau protein in …
H2O2‐responsive multifunctional nanocomposite for the …
2023年2月22日 · In this system, USMA could respond to H 2 O 2 to detach gold nanoparticles (AuNPs) and lead to the release of methylene blue (MB) from mesoporous silica (mSiO 2), …
Effect of H2O2 on HyPer-Tau expressing HeLa cells.: (a
... experiments demonstrate that HyPer-Tau is capable of detecting intracellular H 2 O 2 in a spatially resolved manner. Cells show a subcellular response to both exogenous (Fig. 2) and...
TPPU通过调节PI3K / AKT /GSK-3β途径，保护tau免受H2O2诱导的HEK293 / tau …
本研究调查了sEH抑制剂1-（1-丙酰基哌啶-4-基）-3- [4-（三氟甲氧基）苯基]尿素（TPPU）的作用，H2O2诱导的人胚胎肾293（HEK293）/ Tau细胞中tau磷酸化及其潜在的信号传导途径。
过氧化氢在培养的大鼠少突胶质细胞中诱导tau蛋白的瞬时去磷酸 …
在这项研究中，我们测试了短暂暴露于过氧化氢（H（2）O（2））引起的氧化应激对少突胶质细胞（OL）中tau蛋白磷酸化状态的影响。 从新生大鼠大脑制备的主要少突胶质细胞培养物暴露 …
TPPU protects tau from H2O2-induced ... - Semantic Scholar
The results suggested that the protective effect of TPPU on H2O2-induced oxidative stress is associated with PI3K/Akt/GSK-3β pathway. Neurofibrillary pathology of abnormally …
Caspase-3和caspase-6的协同作用促进了H2O2诱导的D421位点tau …
结论和意义:caspase-3和caspase-6在H2O2引起的D421位点tau蛋白切割中发挥了协同作用,caspase-6可能通过切割caspase-3增强其活性,从而引起更多D421位点tau蛋白的切割.研 …
TPPU protects tau from H2O2-induced hyperphosphorylation in HEK293/tau ...
Neurofibrillary 病理反常地 hyperphosphorylated 字形物是 Alzheimers 疾病(广告) 和另外的 tauopathies 的一个特点.表明小径的 Phosphatidylinositol 3-kinase (PI3K )/Akt/glycogen …