2021年10月19日 · Histamine-2 receptor blockers (H2 blockers) and proton pump inhibitors (PPIs) are two treatment options for heartburn and acid reflux. These two classes of drugs both help …

The relationship between proton-pump inhibitor (PPI) use and chronic kidney disease (CKD) progression remains controversial. Specifically, there is a lack of data evaluating renal outcomes in established CKD patients. The aim of our study is to ...

PPI use, older age, and eGFR ≥ 90 mL/min/1.73 m 2 exhibited high hazard ratios. Conclusions: PPI use was significantly associated with an increased risk of chronic kidney disease …

2016年10月26日 · 与H2受体阻断剂相比，质子泵抑制剂（PPI）是抑制壁细胞内部胃酸分泌的最终过程。 在正常情况下，各种刺激通过多个途径导致胃酸分泌，但最后均需通过质子泵作用引起胃酸分泌。

Proton pump inhibitors (PPIs), followed by histamine 2 receptor antagonists (H2RAs), are the most commonly used drugs to prevent gastrointestinal bleeding in critically ill patients through stress ulcer prophylaxis. The relative efficacy and drug-related adverse events of PPIs and H2RAs remain unclear.

Background: Proton pump inhibitors (PPIs) and histamine type 2 receptor blockers (H2Bs) are used for stress ulcer prophylaxis. Although the PPIs have greater potency for acid suppression, their relative effectiveness for preventing clinically important GI …

Recently, the administration of proton pump inhibitors (PPI) or H 2 receptor antagonists (H 2 RA) has been used commonly for upper gastrointestinal bleeding patients after successful endoscopic therapy [7, 8]; however, the two drugs possess different pharmacological acid …

Proton Pump Inhibitors: Proton pump inhibitors (PPIs) suppress the production of stomach acid and work by inhibiting the proton pump ( H+/K+ ATP-ase). Recent guidelines indicate that PPIs should be the first drug treatment, because they are more effective than H2 blockers.

2019年7月18日 · 摘要：目的 比较质子泵抑制药 (proton pump inhibitors,PPI)和H2受体拮抗药 (histamine-2-receptor antagonists,H2RAs)预防危重患者应激性溃疡的有效性和安全性.方法 对Cochrane图书馆,PubMed,Embase,ScienceDirect数据库,中国知网,中国生物医学文献数据库进行检索.只纳入PPI和H2RA预防应激性 ...

2024年4月8日 · If you experience two or fewer GERD episodes per week and have not been diagnosed with esophagitis, H2 blockers should be your first choice. On the other hand, if you have severe or frequent GERD symptoms, erosive esophagitis, or Barrett's esophagus, then a PPI is the way to go.