DOT1L inhibition reveals a distinct subset of enhancers ... - Nature
2019年6月26日 · Here we reveal that putative enhancers marked with H3 lysine 79 (H3K79) di or trimethylation (me2/3) (which we name H3K79me2/3 enhancer elements or KEEs) can be …
肿瘤表观遗传第二讲——组蛋白甲基化 - 知乎 - 知乎专栏
由dot1l实现的组蛋白h3k79甲基化标记，位于与活性基因表达相关的组蛋白的球状结构域。dot1l也是唯一一种催化赖氨酸甲基化的酶，它与具有set结构域甲基转移酶不同，而h3k79的去甲基化 …
The role of H3K79 methylation in transcription and the DNA …
2019年4月1日 · Taken together, methylation of H3K79 by DOT1L promotes genomic stability at many levels by participating in the regulation of replication timing, DNA damage signaling and …
Science | 李祥团队揭示menin为H3K79me2组蛋白修饰的“阅读器”
2023年2月25日 · 通过染色质免疫沉淀结合高通量测序技术（ChIP-Seq），作者发现menin与H3K79甲基化标记在大量基因上存在共定位，而进一步的生物信息学分析显示，menin可能富 …
靶向H3K79甲基化转移酶DOT1L治疗MLL基因重排型白血病
2022年4月22日 · 近日，湘雅二医院血液内科易彦教授、耳鼻咽喉科葛圣雷副教授在血液学和肿瘤学顶级期刊 《Journal of Hematology & Oncology》（中科院、JCR一区，IF：17.388）上发 …
Regulation of the Dot1 histone H3K79 methyltransferase by
2021年1月22日 · H3K79 methylation by Dot1 is allosterically stimulated by H4K16 acetylation and by H2BK123 ubiquitination. Cross-talk between different histone posttranslational …
Menin “reads” H3K79me2 mark in a nucleosomal context | Science …
2023年2月16日 · We developed a nucleosome-based photoaffinity probe to capture proteins that recognize H3K79 dimethylation (H3K79me2) in a nucleosomal context. In combination with a …
DOT1L and H3K79 Methylation in Transcription and Genomic …
Yeast Dot1 and the mammalian homologue DOT1L are methyltransferases that can add up to three methyl groups to histone H3 lysine 79 (H3K79). H3K79 methylation is implicated in …
Histone H3K79 methylation by DOT1L promotes Aurora B …
2023年8月29日 · Disruptor of telomeric silencing 1 like (DOT1L) is the only known histone methyltransferase that methylates lysine 79 of histone H3 (H3K79), which is located on the …
Menin "reads" H3K79me2 mark in a nucleosomal context
2023年2月17日 · We developed a nucleosome-based photoaffinity probe to capture proteins that recognize H3K79 dimethylation (H3K79me2) in a nucleosomal context. In combination with a …