H3K9me3 - Wikipedia
H3K9me3 is an epigenetic modification to the DNA packaging protein Histone H3. It is a mark that indicates the tri-methylation at the 9th lysine residue of the histone H3 protein and is often …
文献分享 | Nature Cell Biology：在多能细胞中，不同的H3K9me3 …
Distinct H3K9me3 heterochromatin maintenance dynamics govern different gene programmes and repeats in pluripotent cells. Abstract: H3K9me3 heterochromatin, established by lysine …
Nature：张志国团队揭示H3K9me3在DNA复制时的分配机制和生 …
Nov 9, 2023 · H3K9me3作为真核细胞内最重要的抑制性组蛋白修饰，对于抑制基因组内广泛存在的重复序列和维持基因组稳定性是至关重要的。 然而，在DNA复制时其在新合成DNA链的分 …
TNRC18 engages H3K9me3 to mediate silencing of endogenous …
Nov 8, 2023 · Collectively, we describe a new H3K9me3-sensing and regulatory pathway that operates to epigenetically silence evolutionarily young ERVs and exert substantial effects on …
Establishment of H3K9-methylated heterochromatin and its
May 13, 2021 · Heterochromatin is characterized by dimethylated or trimethylated histone H3 Lys9 (H3K9me2 or H3K9me3, respectively) and is found at transposable elements, satellite …
Distinct H3K9me3 heterochromatin maintenance dynamics …
Oct 31, 2024 · H3K9me3 heterochromatin, established by lysine methyltransferases (KMTs) and compacted by heterochromatin protein 1 (HP1) isoforms, represses alternative lineage genes …
The Emerging Role of H3K9me3 as a Potential Therapeutic Target …
H3K9me3 is a dynamic covalent post-translational histone modification which is known to be pathologically deregulated in a number of diseases including haematopoietic malignancies. It …
组蛋白甲基化 | Cell Signaling Technology
就 DNA 序列而言，基因调控也受到甲基化的赖氨酸残基位置的影响。例如，位于启动子的 H3K9me3 与基因抑制相关，而某些诱导基因在基因主体含有 H3K9me3。因为这一修饰是不带 …
Nature | H3K9me3在DNA复制时的分配机制和生物学意义 - 网易
Nov 9, 2023 · 通过生物信息学分析，作者们发现，H3K9me3的不对称分配主要发生在长散在重复序列上（long interspersed nuclear elements，简称LINE或L1） ，尤其是转录方向与DNA复 …
人类早期胚胎发育过程中H3K9me3的重编程图谱 - 澎湃新闻
Here, we profiled genome-wide H3K9me3 in human oocytes and early embryos and discovered stage-specific H3K9me3 deposition on long terminal repeats (LTRs) at the 8-cell and …