a) 髓过氧化物酶 (mpo) 和瓜氨酸化组蛋白 h3 (h3cit)，分别是中性粒细胞和 net 的标志物，在乳腺癌和结肠癌患者的肝转移中含量丰富。 肝脏中 NETs (NET-DNA) 的 DNA 成分通过与 CCDC25 （coiled-coil domain containing protein 25；是一种在癌细胞上表达的跨膜蛋白） 蛋白的高亲和力 ...

研究发现，在体外刺激和炎症条件下，所有检测到的NETotic中性粒细胞也表达citrullinated histone H3 (H3cit)。 这项研究不仅推动了对中性粒细胞功能的理解，也为炎症性疾病的临床诊断和治疗提供了新的科学依据。

2020年7月13日 · In the present study we have evaluated circulating H3cit in stable asthmatics and investigated its relationship with asthma severity, pulmonary function and selected blood and bronchoalveolar lavage (BAL) biomarkers. In 60 white adult stable asthmatics and 50 well-matched controls we measured serum levels of H3cit.

Objectives To investigate whether the levels of citrullinated histone H3 (H3Cit), a biomarker for NET formation, cell-free DNA (cfDNA) and nucleosomes predict venous thromboembolism (VTE) in cancer patients.

In this study, we investigated whether citrullinated histone H3 (H3Cit) could serve as a biomarker for the detection of critical liver damage in sepsis and the efficacy of phosphodiesterase-III inhibition for preventing the liver dysfunction induced by NETosis.

目的 研究瓜氨酸组蛋白 H3 (H3Cit)（NET 形成的生物标志物）、游离 DNA (cfDNA) 和核小体的水平是否可以预测癌症患者的静脉血栓栓塞 (VTE)。 患者/方法 946 名新诊断癌症或缓解后病情进展的患者参加了这项前瞻性观察性队列研究。

2018年8月23日 · In a randomized and placebo-controlled human model of endotoxemia (lipopolysaccharide injection; LPS), we now report significant LPS-induced elevations of circulating H3Cit in 22 healthy...

Recent data propose a diagnostic and prognostic capacity for citrullinated histone H3 (H3Cit), a marker of neutrophil extracellular traps (NETs), in pathologic conditions such as cancer and thrombosis. However, current research is hampered by lack ...

H3Cit immunostaining is a useful tool for identifying activated neutrophils. The frequency of H3Cit+ neutrophils is not only a disease-specific marker but also a potential marker for disease activity in AAV.

Prior studies indicate that neutrophil extracellular traps (NETs) are associated with arterial thromboembolism (ATE) and mortality. We investigated the association between NET formation biomarkers (citrullinated histone H3 [H3Cit], cell‐free DNA ...