H3K27ac is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates acetylation of the lysine residue at N-terminal position 27 of the histone H3 protein. H3K27ac is associated with the higher activation of transcription and therefore defined as an active enhancer mark.

2021年5月10日 · In cancer cells, enhancer hijacking mediated by chromosomal alterations and/or increased deposition of acetylated histone H3 lysine 27 (H3K27ac) can support oncogene expression.

2021年7月8日 · H3K4me3, a modification that is associated with transcriptionally active/poised chromatin (referred to as an active histone mark), exhibits two distinct distribution patterns, both conserved in yeast, plants, worms, flies, and mammals [6, 7, 8].

We first measured the global H3K27ac level by Western blot analysis and observed a moderately reduced bulk H3K27ac level in mutant cells (Fig. 1a), which is expected because mouse ESCs contain much higher levels of canonical H3 histones, …

2025年2月21日 · Histone acetylation, particularly H3 K27 acetylation (H3K27ac), is a critical post-translational modification that regulates chromatin structure and gene expression, which plays a significant role in various cancers, including breast, colon, …

2020年2月21日 · Our results clearly reveal that H3K27ac alone is not capable of functionally determining enhancer activity. Keywords: Enhancer; Gene transcription; H3.3; H3K27 acetylation. H3K27ac is well recognized as a marker for active enhancers and …

2010年12月14日 · We find that histone H3K27ac distinguishes active enhancers from inactive/poised enhancer elements containing H3K4me1 alone. This indicates that the amount of actively used enhancers is lower than previously anticipated.

2019年8月2日 · We found that HDAC1 and HDAC3 inhibition or knockdown results in HDAC7 downregulation, which is associated with a decrease in histone 3 lysine 27 acetylation (H3K27ac) at transcription start...

2023年9月28日 · To address this, we profile epigenomic variation of histone mark H3K27ac across 387 brain, heart, muscle and lung samples from Genotype-Tissue Expression (GTEx). We annotate 282 k active...

2022年10月10日 · H3K27ac marks genomic regions primed for activation including ZGA genes, retrotransposons, and active alleles of imprinted genes. We show that CBP/p300 and HDAC activities play important roles in regulating H3K27ac dynamics and are essential for preimplantation development.