2021年8月20日 · Here, we describe a divergent role for histone H4 lysine 20 mono-methylation (H4K20me1) and demonstrate that it directly facilitates chromatin openness and accessibility by disrupting chromatin...

2013年3月1日 · Disruption of these H4K20-specific histone methyltransferases leads to genomic instability, demonstrating the important functions of H4K20 methylation in genome maintenance. In this review, we explain molecular mechanisms underlying these defects and discuss novel ideas for furthering our understanding of genome maintenance in higher eukaryotes.

2019年2月25日 · We show that BRCA1 recruitment requires recognition of histone H4 unmethylated at lysine 20 (H4K20me0), linking DSB repair pathway choice directly to sister chromatid availability.

2018年9月12日 · SET8 and H4K20 methylation regulate ground-state chromatin compaction in cells exiting mitosis. a U2OS cells were synchronized with double thymidine block. Control and SET8 siRNAs transfected 6 h...

2023年8月17日 · Abini-Agbomson et al. uncover the mechanisms of SUV420H1, a histone H4K20 methyltransferase involved in DNA replication, DNA repair, and heterochromatin formation. They determine several SUV420H1-nucleosome structures to understand its catalytic activity and stimulation by histone variant H2A.Z.

2016年3月1日 · We review the signaling pathways and functions associated with a single residue, H4K20, as a model chromatin and clinically important mark that regulates biological processes ranging from the DNA damage response and DNA replication to gene expression and silencing. The human genome consists of greater than 20,000 protein-coding genes (1).

Histone variant H2A.Z is crucial for early replication origins licensing and activation in which SUV420H1 preferentially recognizes H2A.Z-nucleosome and deposits H4 lysine 20 dimethylation (H4K20me2) on replication origins.

2023年9月25日 · Here, we investigated the effects of one histone mark on histone H4, namely H4K20me3, in the fungus Zymoseptoria tritici, a globally important pathogen of wheat.

2023年9月25日 · Here, we investigated the effects of one histone mark on histone H4, namely H4K20me3, in the fungus Zymoseptoria tritici, a globally important pathogen of wheat.

4 天之前 · Dimethylation of H4K20 is associated with DNA damage response and chromatin compaction. Unlike H4K20me1, which is linked to transcriptional activity, H4K20me2 is more abundant in heterochromatin and serves as a platform for DNA repair protein recruitment. It is catalyzed by SUV4-20H1 and SUV4-20H2, which convert H4K20me1 to its dimethylated state.