The histamine H4 receptor, like the other three histamine receptors, is a member of the G protein-coupled receptor superfamily that in humans is encoded by the HRH4 gene. [5][6][7] Unlike the histamine receptors discovered earlier, H 4 was found in 2000 through a search of the human genomic DNA data base. [8]

Oct 20, 2023 · Histamine is a biogenic amine that participates in allergic and inflammatory processes by stimulating histamine receptors. The histamine H 4 receptor (H 4 R) is a potential therapeutic target for...

Dec 2, 2022 · 组胺受体属于G蛋白偶联受体 (GPCR)，分为四个亚型：H1R、H2R、H3R和H4R。 其中H3R主要表达于神经细胞，在部分肿瘤细胞和嗜酸性粒细胞有表达。 免疫细胞主要以表达H1R、H2R和H4R为主。 组胺结合不同受体，介导不同的免疫调节功能，有时甚至是相反的功能，见下文。 组胺-组胺受体信号通路及生物学功能. 组胺调节免疫细胞功能. T淋巴细胞. 结合H1R促进抗原递呈，促进T细胞活化. 结合H1R促进Th1细胞分化，IFN-γ等效应分子分泌. 结合H2R促 …

Mar 20, 2024 · The histamine H4 receptor (H4R) plays key role in immune cell function and is a highly valued target for treating allergic and inflammatory diseases. However, structural...

Mar 31, 2015 · The histamine H4 receptor (H4R) was first noted as a sequence in genomic databases that had features of a class A G-protein coupled receptor. This putative receptor was found to bind histamine consistent with its homology to other histamine receptors and thus became the fourth member of the histamin …

Oct 24, 2022 · 组胺（Histamine）是一种内源性生物胺，通过作用于G蛋白偶联受体（Gprotein-coupledreceptor，GPCR）家族中的四种不同的组胺受体（H1R、H2R、H3R、H4R）介导多种生理和病理过程。

Oct 3, 2024 · 许多组胺功能由 G 蛋白偶联组胺受体介导，其中包括四个成员，H1R、H2R、H3R 和 H4R。 事实上，长期以来人们一直认为组胺释放引起的炎症反应是由组胺 H1 受体介导的，而 H1 受体拮抗剂（通常称为抗组胺药）多年来一直用于治疗过敏。 常用的组胺H1受体拮抗剂，如苯海拉明、异丙嗪、氯苯那敏等，是目前应用最广泛的非特异性抗过敏药物。 此外，H2受体拮抗剂，如西咪替丁、尼扎替丁、雷尼替丁等，被广泛用于抑制胃酸过度分泌，治疗十二指肠溃疡、 …

Jan 1, 2013 · Histamine H4 receptor (H4R) has become a promising target for immuno-inflammatory diseases, such as allergic rhinitis, asthma or dermal allergies. Its distribution pattern in immune cells and the preclinical data obtained from different biological systems using diverse histamine H4 modulators (1) su …

组胺H4受体 (HRH4)重组蛋白 Recombinant Histamine Receptor H4 (HRH4) GPCR105; GPRv53; H4R; HH4R; H4; AXOR35; BG26; G-protein coupled receptor 105 CD & AM 编号RPG040Hu01 物种Homo sapiens (Human，人) 相同的名称，不同的物种。 所有 人 小鼠 大鼠 豚鼠 家兔 猕猴 山羊 绵羊 马 牛 猪 鸡 狗 其他物种 多物种 泛物种 来源原核表达 宿主E.coli 内 ...

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a Histamine Receptor that is predominantly expressed in haematopoietic cells.