2025年2月11日 · Title: Host biomarkers and biological pathways that are associated with the expression of experimental cerebral malaria in mice. The objective of this study was to test whether amino acid differences among triplicated alpha-globin paralogs are attributable to a relaxation of purifying selection or to a history of positive selection.

2022年10月27日 · Here, we create two mouse strains to test this: an endothelial-specific alpha globin knockout (EC Hba1Δ/Δ) and another with an alpha globin allele mutated to prevent alpha globin’s inhibitory...

2025年2月1日 · Hemoglobin alpha is expressed and is functional in mouse and human T-lymphocytes. Activation and polarization of T-lymphocytes dramatically alters hemoglobin expression. T-lymphocyte hemoglobin impacts mitochondrial …

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Lineage-specific biology revealed by a finished genome assembly of the mouse. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

Homozygotes in which both adult hemoglobin-alpha genes are deleted die late in gestation with symptoms resembling human hydrops fetalis. Allele and strain dependent erythrocyte and …

Gene ID: 15122, updated on 11-Feb-2025. Predicted to enable several functions, including amyloid-beta binding activity; heme binding activity; and oxygen binding activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Involved in response to …

We addressed these questions by examining mice with disrupted Ahsp or α-globin (Hba1) genes and by studying the activities of α-globin, AHSP, and eNOS proteins in cells in culture and in solution. We show that ablation of the Hba1 gene leads to dilated arteries with reduced vasoreactivity and decreased systemic blood pressure.

在Hba-a1基因目的exons两侧分别插入loxP位点。 该flox小鼠可与组织特异性Cre工具鼠交配，获得在特定细胞类型或组织中敲除Hba-a1基因的小鼠模型。 *使用本品系发表的文献需注明: Hba-a1-Flox mice (Cat. NO. 待定) were purchased from Shanghai Model Organisms Center, Inc.. Cre-ERT2在无Tamoxifen诱导的情况下，在细胞质内处于无活性状态；当Tamoxifen诱导后，Tamoxifen的代谢产物4-OHT（雌激素类似物）与ERT结合，可使Cre-ERT2进核发挥Cre重 …

Hba1. Hbat1. Basic Information. Sequence Homology. Transcripts & Proteins. Gene Expression. Protein Interaction . References. Basic Information. Predicted to enable several functions, including heme binding activity; oxygen binding activity; and oxygen carrier activity. Predicted to contribute to haptoglobin binding activity and peroxidase ...

Lineage-specific biology revealed by a finished genome assembly of the mouse. Modulation of T cell development and activation by novel members of the Schlafen (slfn) gene family harbouring an RNA helicase-like motif. Schlafen-8 is essential for lymphatic endothelial cell activation in experimental autoimmune encephalomyelitis.