θ-防御素是于2002年Trabi等用反向高效液相层析色谱法从 猕猴 的 白细胞 中分离出来的1种成 环状 结构分子,又被称为猕猴θ型防御素-1(RTD-1)，主要分布于巨嗜细胞内。

1995年7月17日 · The human beta-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds … We report the isolation and characterization of a novel peptide with significant sequence homology to beta-defensins from human blood filtrate.

2018年11月1日 · Human β-defensin 1 (hBD-1) is a multifaceted antimicrobial peptide being a tumour suppressor and, depending on call of duty, capable of inducing self-nets and neutrophil extracellular traps (NETs) to capture and/or kill bacteria, participates in inflammatory responses in chronic diseases including hBD-3 upregulation and also capable of up ...

2017年3月21日 · Human ß-defensin 1 (hBD1) is an ubiquitously expressed endogenous antimicrobial peptide that exhibits qualitatively distinct activities between its oxidized and reduced forms. Here, we explore these antimicrobial mechanisms.

1995年7月17日 · We report the isolation and characterization of a novel peptide with significant sequence homology to β-defensins from human blood filtrate. The human β-defensin-1 (hBD-1) is a short basic peptide of 36 amino acid residues. It contains six cysteines forming three intramolecular disulfide bonds.

2018年12月21日 · We demonstrated that inhibiting the Epidermal Growth Factor Receptor (EGFR) increased HBD1 expression, whereas activating EGFR repressed HBD1 expression, through the MEKK1/2-ERK1/2 pathway that...

人β-防御素-1 (hBD-1)是一重要的抗菌肽分子,广泛表达于分泌腺和皮肤粘摸的上皮细胞中,具有重要的抗感染功能。 长期以来hBD-1被认为固有表达于各种组织,不被脂多糖 (LPS)等所诱导。 然而近来越来越多的研究表明hBD-1mRNA的表达水平可以被某些微生物及炎性介质上调。 我们实验室发现卡介苗胞壁蛋白组分能够刺激人肺腺上皮细胞SPC-A-1中hBD-1 mRNA的表达增强四倍左右。 hBD-1基因已被克隆,有两个较小的外显子中间隔一6962 bp的内含子。 和人β-防御素-2 (hBD-2) …

1999年12月15日 · hBD-1 mRNA is constitutively expressed by colon epithelial cells, whereas expression of hBD-2 mRNA is up-regulated by IL-1 and enteroinvasive bacteria. RNA from Caco-2 and HT-29 cells was amplified by RT-PCR with primers specific for hBD-1, hBD-2, and β-actin as detailed in Materials and Methods. The first lane contains no RNA.

2013年4月10日 · Human β-defensin 1 (hBD-1) is an antimicrobial peptide expressed by epithelia and hematopoietic cells. We demonstrated recently that hBD-1 shows activity against enteric...

2019年3月6日 · Here we report that proteolysis of reduced hBD-1 by gastrointestinal proteases as well as human duodenal secretions produces an eight-amino acid carboxy-terminal fragment. The generated...