HBMEC from ScienCell Research Laboratories are isolated from human brain. HBMEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. HBMEC are characterized by immunofluorescence with antibodies specific to vWF and/or CD31 (PECAM1).

The HBMEC model poses a restrictive barrier comparable to existing models of the BBB, is of proper cell origin (i.e., human brain microvascular endothelial cells), expresses functional, comparable, mechanisms of transport with respect to Aβ, and is easily maintained.

2020年1月10日 · Here we present a microphysiological platform that recapitulates the key structure and function of the human BBB and enables 3D mapping of nanoparticle distributions in the vascular and...

2016年4月12日 · Recent reports indicate that the derivation of human brain microvascular endothelial cells (hBMECs) from human induced pluripotent stem cells (iPSCs) may provide a solution to this problem. Here we demonstrate the derivation of hBMECs extended to two new human iPSC lines: BC1 and GFP-labeled BC1.

为了建立改进的人体外 BBB 模型，我们比较了四种目前可用且特征良好的永生化人脑毛细血管内皮细胞系 hCMEC/D3、hBMEC、TY10 和 BB19，在屏障紧密度和细胞旁通透性方面。 使用永生化人星形胶质细胞（SVG-A 细胞系）和永生化人周细胞（HBPCT 细胞系）的共培养系统旨在积极影响屏障的紧密性。 方法使用传统的上皮伏欧姆计 (EVOM) 和自动 CellZscope 系统通过跨内皮 …

Because in vitro blood–brain barrier (BBB) models are important tools for studying brain diseases and drug development, we recently established a new line of conditionally immortalized human brain microvascular endothelial cells (HBMEC/ciβ) for use ...

Isolated from human brain. HBMEC are cryopreserved at passage one and delivered frozen. Each vial contains >5 x 105 cells in 1 ml volume. This product has limited…

Human Brain microvascular endothelial cells (BMEC) is the major component of the blood-brain barrier. One of their functions is to limit the passage of soluble and cellular substances from the blood into the brain.

Human Brain Microvascular Endothelial Cells showing early tube formation in culture.

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