2 天之前 · Here we investigated the hepatitis B core protein (HBc) that forms the viral capsids and plays a vital role in the HBV life cycle. We explored two distinct binding pockets on the HBV capsid: the central hydrophobic pocket of HBc-dimers and the pocket at the tips of capsid spikes. We synthesized a geranyl dimer that binds to the central pocket ...

HBV核心蛋白是HBV核衣壳的组成部分，具有重要的生物学特性和功能，且在T细胞和B细胞水平上，HBV核心蛋白的抗原性较HBeAg的更为重要。 因此HBV核心蛋白已逐渐成为抗HBV治疗的新的干预目标。 本文针对HBV核心蛋白的结构、功能，结合HBV核心蛋白变构调节剂的类型和功能等方面，对近年来靶向HBV核心蛋白治疗CHB的研究现状进行综述。...

2020年10月1日 · Targeting the multi-functional core protein is an effective antiviral approach against HBV infection. The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids where viral DNA reverse transcriptional replication takes place and mediates virus-host cell interaction important for the persistence of HBV infection.

2024年8月30日 · Chronic hepatitis B virus (HBV) infection can lead to advanced liver pathology. Here, we establish a transgenic murine model expressing a basic core promoter (BCP)-mutated HBV genome.

2025年3月18日 · Yotsuyanagi, H. et al. Precore and core promoter mutations, hepatitis B virus DNA levels and progressive liver injury in chronic hepatitis B. J. Hepatol. 37(3), 355–363 (2002).

2021年1月2日 · HBc是构成HBV病毒衣壳的唯一结构分子，由183个氨基酸组成，包括衣壳装配必需的N端结构域（N-terminal domain，NTD，aa 1-140）和非必需的C端结构域（C-terminal domain，CTD，aa 150-183）。CTD中包含控制HBc出入细胞核的基序，并具有DNA/RNA结合和分子伴侣的活性。

3 天之前 · Hepatitis B virus (HBV) infection is a global public health issue, affecting nearly one billion people worldwide ().It is a significant cause of morbidity and mortality, including acute and chronic hepatitis and hepatocellular carcinoma (HCC) ().Although HBV primarily affects liver disorders, recent studies suggest that it may also be associated with other types of cancers outside the liver.

2025年3月13日 · Hepatitis B core-related antigen (HBcrAg) assay quantifies, using a chemiluminescence immunoassay, HBcAg, HBeAg, and the p22 core-related protein, a phosphorylated form of HBcAg. 16,17 Serum HBcrAg concentrations have shown strong correlation with serum HBV DNA concentrations and intrahepatic covalently closed circular DNA levels in untreated ...

2019年11月7日 · Hepatitis B virus (HBV) production requires intricate interactions between the envelope and core proteins. Analyses of mutants of these proteins have made it possible to map regions involved in...

Hepatitis B virus employs two very closely related proteins; core to form its capsid and pre-core to modulate the host immune response. Eren et al. describe how two exceptionally high-affinity humanized antibody fragments bind to and block both of these proteins and propose how they may function as therapeutics.