Hepatitis B virus (HBV) can replicate within hepatocytes without causing direct cell damage. The host immune response is, therefore, not only essential to control the spread of virus infection, but it is also responsible for the inflammatory events causing liver pathologies.

This review will discuss the mechanisms of central and peripheral tolerance/exhaustion of adaptive immunity in the context of chronic HBV infection. We also cover the interaction of HBV with cells of the innate immune system and propose concepts for the heterogeneity of responses in chronically infected patients.

Chronic infection with the hepatitis B virus (HBV) is typically established neonatally and progresses through different phases. Historically, the phases have been designated as immune tolerant (IT); HBeAg +, immune active (IA +); HBeAg −, …

HBV infection stimulates quick immune responses, which usually appears as an acute self-restriction infection and brings lifetime immunity in adults; however, in newborns and children, the infection may become chronic with lifetime virus persistence [11].

2022年6月30日 · There is a safe and effective hepatitis B vaccine that helps a person build immunity against HBV infection. Learn more about hepatitis B, including what it means to have immunity and how the...

2021年5月17日 · Hepatitis B virus (HBV), the prototypical member of the Hepadnaviridae family, is a non-cytopathic DNA virus that is transmitted by contacts with infected blood and body fluids and triggers...

The immune response initiated by the T-cell response to viral antigens is thought to be fundamental for viral clearance and disease pathogenesis in hepatitis B virus (HBV) infection. The T-cell response during acute self-limited hepatitis B in people is characterised by a vigorous, polyclonal, and multispecific cytotoxic and helper-T-cell response.

Hepatitis B virus (HBV) is an ancient virus that has evolved unique strategies to persist as a chronic infection in humans. Here, I summarize the innate and adaptive features of the HBV-host interaction, and I discuss how different profiles of antiviral immunity cannot be …

2022年3月7日 · Persistent CHB infection arises as a consequence of complex interactions between the virus and the host innate and adaptive immune systems. Therefore, understanding the immune escape mechanisms involved in persistent HBV infection is important for designing novel CHB treatment strategies to clear HBV and achieve long-lasting immune control.

2017年6月1日 · Clinical events and the host immune response during hepatitis B virus (HBV) infection are intricately linked. Despite decades of research, important questions concerning the immunopathogenesis of chronic HBV infection remain unanswered.