Hepatitis C is a blood-borne virus that causes scarring and inflammation of the liver. 1 The virus is also associated with extrahepatic disease, including non Hodgkins lymphoma, 2 renal disorders 3 and, probably, cardiovascular disease. 4 Chronic hepatitis C virus (HCV) infection-referring to persistent carriage of the virus is a global problem ...

The Swiss Hepatitis C Cohort Study (SCCS) was established in 2000 as a joint effort between the Swiss Group of Experts in Viral Hepatitis and the Swiss Association for the Study of the Liver.

2023年8月14日 · This large population-based cohort study demonstrated the marked beneficial association between hepatitis C treatment and mortality. The high mortality rates observed among HCV infected and untreated persons highlights the need to prioritize linkage to care and treatment to achieve elimination goals …

2020年7月25日 · We evaluated changes in causes of death among Swiss Hepatitis C Cohort Study (SCCS) participants from 2008 to 2016. We analyzed risk factors for all-cause and cause-specific mortality, accounting for changes in treatment, fibrosis …

2024年3月25日 · Background and aims: Data on the prevalence and characteristics of so-called rare HCV genotypes (GTs) in larger cohorts is limited. This study investigates the frequency of rare GT and resistance-associated substitutions and the efficacy of …

Most were white (DAA-treated cohort, 79.9%; untreated cohort, 79.2%) and had HCV GT1a infection (56.1% vs. 60.8%). Compared with the untreated cohort, people in the treated cohort were more likely to have cirrhosis (43.5% vs. 15.4%, p<0.0001), a higher severity of Charlson comorbidity index (p<0.0001), and a history of kidney (1.7% vs. 0.7%, p ...

2019年4月6日 · We compared the incidence of death, hepatocellular carcinoma, and decompensated cirrhosis between patients treated with direct-acting antivirals and those untreated, in the French ANRS CO22 Hepather cohort. We did a prospective study in adult patients with chronic HCV infection enrolled from 32 expert hepatology centres in France.

A study conducted in England using the Trent Hepatitis C cohort also suggested that there was no difference in liver-related mortality risk between sexes . On the other hand, a study in the U.S. indicated that individuals with chronic HCV had more than twice the all-cause mortality rate compared to non-HCV infected individuals, with rates being ...

A propensity score matched (PSM) cohort of HCV mono-infected (n = 7020) and HBV/HCV (n = 702) co-infected patients by age, sex, and fibrosis was recruited for outcome analysis. The primary outcome was liver-related complications, including hepatocellular carcinoma (HCC) and liver decompensation during a mean follow-up period of 4.44 years.

2021年4月25日 · Here, we report the results of a large prospective observational real-world cohort study, in order to assess the rate of disease outcomes and overall survival in patients with chronic HCV disease treated with DAAs, to analyse the rate of liver-related (LR) and cardiovascular (CV) deaths, and to identify risk factors associated with mortality ...