Hepatitis C - StatPearls - NCBI Bookshelf - National Center for ...
2023年3月26日 · First diagnosed in 1989, the hepatitis C virus (HCV) is a significant public health problem affecting 58 million people worldwide. The percentage of people who are seropositive …
HCV Genome and Life Cycle - Hepatitis C Viruses - NCBI Bookshelf
Herein, we summarize our current understanding of the HCV genome and how its structure and encoded gene products, in a complex interplay with host cell factors, might orchestrate a …
Hepatitis C virus: Virology, diagnosis and treatment - PMC
More than twenty years of study has provided a better understanding of hepatitis C virus (HCV) life cycle, including the general properties of viral RNA and proteins. This effort facilitates the …
Hepatitis C Viruses - NCBI Bookshelf - National Center for ...
The discovery of the causative agent, hepatitis C virus (HCV), in 1989 has initiated an almost unparalleled research activity in academic and pharmaceutical-industry laboratories over the …
Hepatitis C virus: Morphogenesis, infection and therapy - PMC
Hepatitis C virus (HCV) is a major cause of liver diseases including liver cirrhosis and hepatocellular carcinoma. Approximately 3% of the world population is infected with HCV. …
Hepatitis C virus: life cycle in cells, infection and host response ...
The Hepatitis C virus (HCV) was identified in 1989. This year marks a departure from traditional virology, based on isolation, cultivation, and biochemical studies, to modern virology that uses …
HCV virology and diagnosis - PubMed
Hepatitis C virus (HCV) infection is a major cause of severe liver disease including chronic hepatitis, cirrhosis and hepatocellular carcinoma. The HCV burden in public health is …
NSUN2-mediated HCV RNA m5C Methylation Facilitates Viral RNA …
2025年2月17日 · HCV RNA genomic m5C specific abrogating mutation at C7525 site reduces viral replication, assembly, and budding through decreasing viral RNA stability. Deficiency of …
The Natural History of Hepatitis C Virus Infection and Disease in …
2025年2月26日 · The availability of highly effective direct-acting antivirals (DAAs) that cure individuals infected with HCV has changed completely the natural history of HCV infection and …
HCV Helicase: Structure, Function, and Inhibition
Fueled by ATP hydrolysis, this movement allows the protein to displace complementary strands of DNA or RNA and proteins bound to the nucleic acid. HCV helicase shares two domains …