研究发现ntcp为hcv感染的宿主依赖因子，进一步强调了其在病毒-肝细胞相互作用中的重要作用。 NTCP靶向抗病毒药物增强先天抗病毒应答和参与宿主免疫系统清除感染的潜力可能是治疗所有嗜肝病毒，包括HBV、HCV和HDV的有用特性。

2024年9月1日 · Moreover, NTCP modulates HCV infection by enhancing BA-mediated inhibition of IFN-stimulated genes (ISGs). The regulatory function of NTCP in intrinsic hepatic immunity has been elucidated, providing insights into the intricate …

2022年1月4日 · 此外，NTCP 还影响丙肝病毒 (HCV) 感染过程，其中NTCP通过胆汁酸介导的干扰素刺激基因 (ISG) 抑制来调节HCV感染。 基于上述发现，近年来全球科研人员已将NTCP作为抑制HBV和HCV感染的热门药物靶点。 NTCP作为药物开发的目标方面，HBV进入和胆汁酸转运蛋白在 NTCP上具有共同的分子决定因素，研究NTCP活性对于阻断HBV感染就显得至关重要。 然而，研究人员也发现，NTCP对胆汁酸的低摄取并不一定会影响HBV 的进入，因此并非所有抑制胆汁 …

2016年10月25日 · Recently, the solute carrier and sodium taurocholate co-transporter NTCP has been identified as a receptor for HBV and HDV. Here, we uncover NTCP as a host factor regulating HCV infection. Using gain- and loss-of-function studies, we show that NTCP mediates HCV infection of hepatocytes and is relevant for cell-to-cell transmission.

2014年2月19日 · Identification of NTCP as an HBV entry receptor has accelerated the understanding of HBV molecular biology and offered useful experimental systems to analyze the HBV and HDV lifecycle, including the identification of host restriction and dependency factors. NTCP also represents a new therapeutic target in the development of new anti-HBV agents.

2014年2月10日 · Recent studies have revealed that human sodium taurocholate cotransporting polypeptide (SLC10A1 or NTCP) is a functional cellular receptor for hepatitis B virus (HBV). However, whether human...

2016年10月25日 · Recently, the solute carrier and sodium taurocholate co-transporter NTCP has been identified as a receptor for HBV and HDV. Here, we uncover NTCP as a host factor regulating HCV infection. Using gain- and loss-of-function studies, we show that NTCP mediates HCV infection of hepatocytes and is relevant for cell-to-cell transmission.

Recently, NTCP has been shown to modulate HCV infection of hepatocytes by regulating innate antiviral immune responses in the liver. Here, we review the current knowledge of the functional role and the molecular and cellular biology of NTCP in the life cycle of the three major hepatotropic viruses, highlight the impact of NTCP as an antiviral ...

2025年1月13日 · 研究发现ntcp为hcv感染的宿主依赖因子，进一步强调了其在病毒-肝细胞相互作用中的重要作用。 NTCP靶向抗病毒药物增强先天抗病毒应答和参与宿主免疫系统清除感染的潜力可能是治疗所有嗜肝病毒，包括HBV、HCV和HDV的有用特性。

2018年2月1日 · Recently, the bile acid transporter NTCP, mainly expressed at the cell surface of hepatocytes, was described as the first bona-fide receptor for both HBV and HDV. Moreover, this solute carrier was shown to be involved in the modulation of HCV entry, confirming its importance in liver infection by hepatic viruses.