The p7 protein is a small, hydrophobic transmembrane protein that participates in viral assembly and release. The p7 protein can oligomerize as hexamers to form ion channels in host cell …

p7, a 63-residue peptide encoded by hepatitis C virus (HCV), a major pathogen associated with a risk of developing severe liver disease, is involved in ion channel activity in lipid bilayer …

The role of p7 in the HCV life cycle is presently uncertain, but most of the research performed to date highlights its role in the virus assembly process. The aim of this review is to provide an …

2019年6月10日 · A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-alpha-2b and …

2017年12月18日 · Hepatitis C virus (HCV) encodes a viroporin, p7, acting during assembly, envelopment and secretion of viral particles (VP). HCV p7 is released from the viral …

2007年7月20日 · The hepatitis C virus (HCV), a major human pathogen associated with severe liver disease, encodes a small membrane protein designated p7. Although recent reports …

2015年8月6日 · This review compiles the most recent findings related to the structure and dual pore/ion channel activity of p7 of different HCV genotypes. The alternative conformations and …

Hepatitis C virus (HCV) p7 is an integral membrane protein that forms ion channels in vitro and that is crucial for the efficient assembly and release of infectious virions. Due to these …

hcv-p7 表达抑制了 tnf-α 介导的 iκb-α 降解和随后的 nf-κb 启动子活性，揭示了 p7 新的功能性抗炎作用。 总之，这些发现确定了 HCV-p7 通过 STAT3 和 ERK 激活诱导 SOCS3 的分子机制， …

p7, a 63-residue peptide encoded by hepatitis C virus (HCV), a major pathogen associated with a risk of developing severe liver disease, is involved in ion channel activity in lipid bilayer …