The Metastasis-associated Proteins 1 and 2 Form Distinct Protein ...
2003年10月24日 · Our experimental data showing that both MTA1 and MTA2 form distinct protein complexes with HDAC1 and HDAC2 support this hypothesis. Furthermore, our purification of …
Histone deacetylase complexes: Structure, regulation and function
2024年9月1日 · HDAC complexes play vital roles in the regulation of key biological processes such as transcription, replication, and DNA repair. Moreover, deregulated HDAC complex …
The Nucleosome Remodeling and Deacetylase Complex Has an …
2020年12月1日 · NuRD is built from a 2:2:4 (MTA, HDAC, and RBBP) deacetylase module and a 1:1:1 (MBD, GATAD2, and Chromodomain-Helicase-DNA-binding [CHD]) remodeling module, …
Overall Structure of the HDAC1:MTA1 Complex - ResearchGate
Class I histone deacetylases (HDAC1, HDAC2, and HDAC3) are recruited by cognate corepressor proteins into specific transcriptional repression complexes that target HDAC …
Collateral lethality between HDAC1 and HDAC2 exploits cancer …
2023年7月24日 · Here we unveil a genetic interaction between histone deacetylase 1 (HDAC1) and HDAC2, wherein each paralog is synthetically lethal with hemizygous deletion of the other.
Role of MTA1 in Cancer Progression and Metastasis - PMC
The acetylated MTA1 allows its interaction with HDAC – presumably the acetylated substrate serves as a docking platform for HDAC – to form the MTA1-HDAC/NuRD complex to repress …
Towards an understanding of the structure and function of MTA1
2014年10月29日 · The class I histone deacetylase (HDAC) corepressor complexes are multi-protein assemblies that contain one or more enzymes that modify chromatin, components with …
HDACs, histone deacetylation and gene transcription: from
2007年2月27日 · MTA-2 is an essential component of an enzymatically active recombinant HDAC1/HDAC2 protein complex, while in CoREST the SANT domain is necessary for …
Regulating the Regulators: The Role of Histone Deacetylase 1 …
Histone deacetylases (HDACs) catalyze the removal of acetyl groups from the ε-amino groups of lysine residues. The reversible acetylation of histones and non-histone proteins by histone …
NuRD is built from a 2:2:4 (MTA, HDAC, and RBBP) deacetylase module and a 1:1:1 (MBD, GATAD2, and Chromodomain-Helicase-DNA-binding [CHD]) remodeling module, and the …