2018年7月18日 · In this Review, we provide an overview of the control of CD4 + T cell immunity by members of the HDAC family. We first summarize the basic principles and known functions …

HDAC在各种实体瘤中过表达或过度活跃，并抑制肿瘤抑制基因的表达，从而导致增殖不受控制以及对细胞修复机制和细胞凋亡不敏感。 因此，HDAC也是开发特异性抗癌药物的潜在靶点。 …

Multi-omics analyses reveal that HDAC1 controls expression, chromatin accessibility, and histone acetylation of the transcription factors IRF4, IRF8, and SPIB required for efficient development …

2016年8月15日 · Using the HDACi romidepsin in vivo, we observed increased chemokine expression, enhanced T-cell infiltration, and T-cell-dependent tumor regression. Importantly, …

2024年4月23日 · Here, we identify class I histone deacetylase inhibitors (HDACi) as boosters of CAR-T cell function by high-throughput screening of chromatin-modifying drugs, in which …

2024年9月1日 · HDAC complexes play vital roles in the regulation of key biological processes such as transcription, replication, and DNA repair. Moreover, deregulated HDAC complex …

The use of both genetic KOs and class I HDAC specific inhibitors has highlighted the importance of HDAC1/2 in removing acetylation from high stoichiometry sites on histone tails ... Unpaired t …

2024年4月4日 · Class I HDACi enhance persistence and in vivo antitumor efficacy of CAR-T cells. Epigenetic modification shapes differentiation trajectory and regulates the exhaustion state of …

2025年2月15日 · Several HDAC inhibitors (HDACis), such as vorinostat, romidepsin, and belinostat, have received approval for the treatment of cutaneous T-cell lymphoma or …

Histone Deacetylase 3 (HDAC3) function in vivo is nuanced and directed in a tissue-specific fashion. The importance of HDAC3 in Kras mutant lung tumors has recently been identified, …