HDAC10 Gene - GeneCards | HDA10 Protein | HDA10 Antibody
2024年12月25日 · HDAC10 (Histone Deacetylase 10) is a Protein Coding gene. Diseases associated with HDAC10 include Neuroblastoma and Conjugate Gaze Palsy. Among its …
HDAC10 - Wikipedia
Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. [5][6][7] HDAC10 is a class IIb HDAC. It specifically has selectivity for long, slender polyamines like N8 …
一文带你了解组蛋白去乙酰化酶（HDAC） - 知乎专栏
hdac8和hdac11则优先水解非乙酰酰基赖氨酸底物，hdac10则是一种多胺去乙酰化酶。 HDAC催化机制 乙酰赖氨酸底物位于一个由疏水残基围绕的狭窄通道中，其中酪氨酸残基通过构象翻转 …
Histone deacetylase 10 structure and molecular function as a …
2017年5月18日 · Here we report that histone deacetylase 10 (HDAC10) is a robust polyamine deacetylase, using recombinant enzymes from Homo sapiens (human) and Danio rerio …
聚焦药靶：HDAC抑制剂的最新研究进展 - 健康界
2021年9月6日 · 西达本胺由微芯生物开发的亚型选择性HDAC抑制剂，针对HDAC第I类的1、2、3亚型和第IIb类的10亚型，属于表观遗传调控剂类药物，具有对肿瘤发生发展相关的表观遗传 …
Histone deacetylase 10: A polyamine deacetylase from the crystal ...
2023年10月1日 · HDAC10 possesses unique substrate selectivity. HDAC10 is the only polyamine deacetylase identified so far. Structural insights in HDAC10 led to efficient substrates and the …
Structural Basis for the Selective Inhibition of HDAC10, the …
The cytosolic class IIb histone deacetylase HDAC10 is an emerging target for drug design. As an inducer of autophagy, its selective inhibition suppresses the autophagic response that …
83933 - Gene ResultHDAC10 histone deacetylase 10 [ (human)]
2025年2月8日 · HDAC10 suppresses expression of matrix metalloproteinase (MMP) 2 and 9 genes, which are known to be critical for cancer cell invasion and metastasis; results …
Dual role of HDAC10 in lysosomal exocytosis and DNA repair
2018年7月3日 · Here, we show that depleting or inhibiting HDAC10 results in accumulation of lysosomes in chemotherapy-resistant neuroblastoma cell lines, as well as in the intracellular …
Science子刊：曹雪涛/姜明红/朱平合作揭示组氨酸去乙酰化酶促进I…
2022年12月23日 · HDAC10以脱乙酰酶不依赖的方式与未感染细胞的IRF3结合，通过TANK结合激酶1 (TANK-binding kinase 1，TBK1)抑制IRF3 Ser 396 位点的磷酸化。病毒感染 …