HDAC8 - Wikipedia
Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene. [5][6][7] Histones play a critical role in transcriptional regulation, cell cycle progression, and …
HDAC8 as a target in drug discovery: Function, structure and design
2024年12月15日 · HDAC8 has emerged as an important target in the field of pharmacology. This review summarizes the latest advancements and clinical research on HDAC8 inhibitors and …
一文带你了解组蛋白去乙酰化酶（HDAC） - 知乎专栏
hdac8和hdac11则优先水解非乙酰酰基赖氨酸底物，hdac10则是一种多胺去乙酰化酶。 HDAC催化机制 乙酰赖氨酸底物位于一个由疏水残基围绕的狭窄通道中，其中酪氨酸残基通过构象翻转 …
HDAC8 Gene - GeneCards | HDAC8 Protein | HDAC8 Antibody
2024年12月25日 · Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the …
Histone deacetylase 8 (HDAC8) and its inhibitors with ... - PubMed
2019年2月15日 · The histone deacetylases (HDACs) enzymes provided crucial role in transcriptional regulation of cells through deacetylation of nuclear histone proteins. Discoveries …
Binding mechanism and distant regulation of histone ... - Nature
2025年2月12日 · Histone deacetylase 8 (HDAC8) is a well-known epigenetic regulator for cancer therapy. However, developing targeted inhibitors for HDAC8 is challenging due to a limited...
HDAC8: a multifaceted target for therapeutic interventions
2015年7月1日 · Histone deacetylase 8 (HDAC8) is a class I histone deacetylase implicated as a therapeutic target in various diseases, including cancer, X-linked intellectual disability, and …
55869 - Gene ResultHDAC8 histone deacetylase 8 [ (human)]
2025年2月8日 · HDAC8 inhibits cytotoxicity induced by cobalt and hypoxia/reoxygenation, in part, through suppressing DRP1 expression and mitochondrial fission. HDAC8 enhances the in vitro …
HDAC8: A Promising Therapeutic Target for Acute Myeloid …
2020年9月4日 · Histone deacetylase 8 (HDAC8), a class I HDAC that modifies non-histone proteins such as p53, is highly expressed in different hematological neoplasms including a …
余巍课题组发现HDAC8的可逆乙酰化修饰调控细胞周期的新机制
2024年7月26日 · HDAC8是一种Zn²⁺依赖型的I类去乙酰化酶HDAC，通过催化粘连蛋白cohesin亚基SMC3去乙酰化，在细胞周期过程中发挥重要作用。 HDAC8过表达能够增强多种癌细胞的 …