Unlocking the potential of hydrogen deuterium exchange via an
2025年2月3日 · In this active field of research, metal-catalysed hydrogen deuterium exchange (HDE) has been extensively explored and has recently provided a plethora of procedures for …
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Practical synthesis of C1 deuterated aldehydes enabled by NHC
2019年10月28日 · High yielding hydrogen–deuterium exchange (HDE) processes catalysed by Ir (Fig. 1b, reaction F, D 2 as deuterium source) 33 or Ru (reaction G, D 2...
Advances in C1-deuterated aldehyde synthesis - ScienceDirect
2022年7月15日 · The recent surge in deuterated pharmaceutical compounds has created an urgent demand for new synthetic tools that allow facile access to D-containing building blocks. …
Site-selective deuteration at the α-position of enals by an amine …
2022年9月15日 · An amine and bis(phenylsulfonyl)methane co-catalyzed hydrogen–deuterium exchange (HDE) method via a Michael-retro-Michael pathway for site-selective introduction of …
Unlocking the potential of hydrogen deuterium exchange via an …
2025年2月3日 · This report pinpoints an approach to unlock the potential of HDE using the concept of iterative runs in continuous-flow technology (recirculation process). This closed …
通过氯自由基介导的甲酰基 C-H 键选择性氘化进行 C-1-氘代醛的 …
理想情况下，氢-氘交换（hde）是最有效的方法。 然而，用于产生 C-1-氘代醛的传统 HDE 通常需要涉及多种催化剂和/或配体的复杂系统。 在本研究中，我们提出了甲酰基 C-H 键与 D 2 O 的 …
Hydrogen-Deuterium Exchange in Basic Near-Critical and
2020年4月2日 · Treatment of homo- and heterocyclic aromatic substrates with basic deuterium oxide under near- or supercritical conditions results in rapid base-catalyzed hydrogen …
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Deuteration of Formyl Groups via a Catalytic Radical H/D Exchange ...
Direct hydrogen-deuterium exchange (HDE) processes with aldehydes without requiring additional functional group transformation represent an even more synthetically efficient strategy. Tuttle …
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