Lecithin–cholesterol acyltransferase (LCAT, also called phosphatidylcholine–sterol O-acyltransferase) is an enzyme found in many animals, including humans. It converts free …

2020年1月15日 · Lecithin:cholesterol acyltransferase (LCAT) catalyzes a critical step of reverse cholesterol transport by esterifying cholesterol in high density lipoprotein...

hdl核心是lcat酶反应产物 胆固醇酯 的 贮存库 ，并通过 胆固醇酯转移蛋白 将ce转移至其他脂蛋白和 细胞膜 ，并与其交换。 LCAT除 肝细胞 合成外，在小肠、脾、胰、胎盘、 肾上腺 等 组织 …

Lecithin:cholesterol acyltransferase (LCAT) is a key enzyme in lipoprotein metabolism that enables the maturation of high-density lipoprotein (HDL) particles. LCAT esterifies free …

2022年3月1日 · LCAT esterifies cholesterol and nascent HDL is modified into spherical HDL 3. FCh can also be transferred to HDL 3 via ABCG1, ABCG4 or spontaneously leaving …

Lecithin cholesterol acyltransferase (LCAT) (EC2.3.1.43), a lipoprotein-associated enzyme, is a key player in the reverse cholesterol transport (RCT) pathway, which promotes the transfer of …

2024年2月24日 · LCAT is an enzyme attached to both high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles and is responsible for the esterification of cholesterol, a …

2014年1月1日 · LCAT esterifies free cholesterol on the surface of HDL, forming cholesteryl esters which then partition into the lipoprotein core, resulting in the formation of mature spherical HDL …

LCAT catalyzes the conversion of free cholesterol to cholesteryl esters on HDL particles, generating a cholesterol concentration gradient that promotes cholesterol outflow from cell …

6 天之前 · LCAT activity is essential for the formation of mature high-density lipoprotein (HDL) and the remodeling of HDL particles [13,14,15,16,17]. Traditionally, LCAT has been considered …