High-density lipoproteins (HDL) are important endogenous inhibitors of inflammatory responses. Functional impairment of HDL might contribute to the excess mortality experienced by patients with liver disease, but the effect of cirrhosis on HDL metabolism and function remain elusive.

2022年9月26日 · HDL synthesis occurs in the liver and the intestines. The first step of HDL synthesis involves the production of its main structural apolipoproteins, Apo-AI. Apo-AI is the structural protein of HDL and receives cholesterol and phospholipids from enterocytes and hepatocytes via transporter ABCA1, forming pre-beta HDL.

2021年7月23日 · All showed that intestinally derived HDL reduced liver injury. From a therapeutic perspective, oral delivery of LXR agonists proved effective in protecting the liver by upregulating HDL within the intestine, consistent with another recent study that engineered mice so that LXR activity was genetically augmented selectively in the intestine ...

Results: In the analysis group, albumin, bilirubin, INR, and Model for End-Stage Liver Disease (MELD) score correlated strongly with high-density lipoprotein (HDL) cholesterol, weakly but significantly with total cholesterol and very-low-density lipoprotein cholesterol (VLDL), and poorly with low-density lipoprotein cholesterol (LDL ...

Dietary cholesterol is also transferred from the intestine to the liver by HDL; all HDL particles are internalized in the liver, interacting with the hepatic scavenger receptor (SR-B1). Once in the hepatocyte, cholesterol delivered by HDL particles may be utilized for hepatic cholesterol needs, converted into bile acids, or excreted into bile ...

2021年7月23日 · The biogenesis of high-density lipoprotein (HDL) requires apoA1 and the cholesterol transporter ABCA1. Although the liver generates most of the HDL in the blood, HDL synthesis also occurs in the small intestine. Here, we show that intestine-derived HDL traverses the portal vein in the HDL 3 …

2023年9月1日 · Non-alcoholic fatty liver disease (NAFLD) is associated with reduced HDL levels. The cholesterol efflux capacity of HDL particles is impaired in NAFLD patients. NAFLD is associated with marked changes in the HDL particle lipidome and proteome. HDL production by cultured hepatocytes protects against lipid accumulation.

2019年7月21日 · Alterations in hepatic lipid metabolism can contribute to the development of chronic liver disease, such as nonalcoholic fatty liver disease (NAFLD) and add to the progression of other chronic liver disease, as occurs in hepatitis C.

The major structural protein component of HDL is apolipoprotein A-I (apoA-I), formed in both the liver (~80%) and intestine (~20%) and secreted in a lipid-free state. Efflux of phospholipids and free cholesterol on to at least 2 molecules of apoA-I stimulate the biogenesis of HDL, resulting in the generation of a discoidal lipid-poor ‘nascent ...

4 天之前 · Wang, K. et al. Non-HDL-cholesterol to HDL-cholesterol ratio is a better predictor of new-onset non-alcoholic fatty liver disease than non-HDL-cholesterol: A cohort study. Lipids Health Dis. 17 , 196.