HE4 is a small circulating peptide and a sensitive detection kit has been developed. Combining the use of HE4 with CA-125 has improved diagnostic specificity by excluding some benign conditions. HE4 can be used for stratification of patients with a pelvic mass.

The HE4 blood test is ordered to determine either the recurrence or progression of ovarian cancer. Ovarian cancer can recur in women who have been cancer-free for some time, so this blood test is often part of a recall program where progress is monitored.

Jan 6, 2025 · HE4, or Human Epididymis Protein 4, is a biomarker found in the blood that has shown remarkable potential in identifying ovarian cancer with greater accuracy than traditional tests like CA-125.

Apr 24, 2020 · Human epididymis protein 4 (HE4) is a protein that is produced by most, but not all, epithelial ovarian cancer cells. An HE4 test may be used along with CA-125 for women who have been treated for epithelial ovarian cancer to monitor the effectiveness of treatment and for recurrence of the cancer.

Serum human epididymis protein 4 (HE4) is significantly higher in patients with endometrial cancer compared to patients without endometrial cancer and is associated with a poorer prognosis. This makes HE4 an attractive candidate for clinical use in endometrial cancer.

HE4 levels tend to be higher in older women and in women who began menstruating at an older age, but these affects are small. 1 Falsely elevated or depressed values of HE4 may occur in samples containing human antimouse antibodies. 2 Levels of HE4 within the reference range do not preclude the presence of cancer, nor are elevated results an ...

HE4, Ovarian Cancer Monitoring - The percentage increase in HE4 values has been used as an aid in monitoring recurrence or progressive disease in patients with invasive epithelial ovarian cancer. Currently there is no clinically accepted cut-off for use in monitoring cancer progression in epithelial ovarian cancer subjects with this assay.

The Roche Elecsys HE4 (human epididymal protein 4) assay is a sandwich electrochemiluminescence immunoassay that employs a biotinylated monoclonal HE4-specific antibody and a monoclonal HE4-specific antibody labeled with ruthenium complex.

Nov 2, 2014 · To assess the possible limitations or benefits of HE4 in a clinical setting, this review aims to systematically outline published results of HE4 tissue expression and serum HE4 levels in healthy individuals and patients with benign or malignant tumors.

The human epididymis protein 4 (HE4) has recently been approved by the Food and Drug Administration for monitoring recurrence or progression of epithelial ovarian cancer. Nevertheless, reliable clinical evidence demonstrates that HE4, used alone or in combination with CA125, substantially improves the accuracy of screening and/or disease ...