2024年12月25日 · HEXIM1 (HEXIM P-TEFb Complex Subunit 1) is a Protein Coding gene. Diseases associated with HEXIM1 include Nut Midline Carcinoma and Immune Deficiency Disease. Among its related pathways are Initiation of transcription and translation elongation at the HIV-1 LTR and Chromatin Regulation / Acetylation.

六亚甲基双乙酰胺诱导蛋白 1 (HEXIM1) 是众所周知的正转录延伸因子 b (P-TEFb) 的抑制剂，它控制 RNA 聚合酶 II 的转录延伸和人类免疫缺陷病毒的 Tat 反式激活。

"Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors". Cancer Res. 63 (16): 5151–8.

2017年8月3日 · HEXIM1 and the NEAT1 long non-coding RNA form a platform to assemble the rest of the complex, including components of the DNAPK-cGAS-TBK1-IRF3 signaling cascade. Silencing either HEXIM1 or NEAT1 disrupts the HDP-RNP complex and decreases cytosolic DNA-dependent IFN production.

2023年12月21日 · HEXIM1 regulates erythroid proliferation and fetal globin expression in a positive transcription factor β–dependent manner. GATA1 co-occupancy determines whether HEXIM1 functions as an activator or a repressor at specific loci.

This gene has 1 transcript (splice variant), 116 orthologues and 1 paralogue. 该基因的表达由六亚甲基双乙酰胺在血管平滑肌细胞中诱导。 该基因没有内含子。 [RefSeq 提供，2008 年 7 月] Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

2025年2月8日 · HEXIM1 is an essential transcription regulator during human erythropoiesis. UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat. Downregulation of Dihydrotestosterone and Estradiol Levels by HEXIM1.

Hexim1 acts as a tumor suppressor and is involved in the regulation of innate immunity. It was initially described as a non-coding RNA-dependent regulator of transcription. Here, we detail how 7SK RNA binds to Hexim1 and turns it into an inhibitor ...

Hexim1 acts as a tumor suppressor and is involved in the regulation of innate immunity. It was initially described as a non-coding RNA-dependent regulator of transcription. Here, we detail how 7SK RNA binds to Hexim1 and turns it into an inhibitor of …

2023年12月21日 · We identified a key role for HEXIM1 in controlling erythroid gene expression and function, with overexpression of HEXIM1 promoting erythroid proliferation and fetal globin expression. HEXIM1 regulated erythroid proliferation by enforcing RNAPII pausing at cell cycle check point genes and increasing RNAPII occupancy at genes that promote cycle ...