Mar 30, 2025 · HEXIM1 (HEXIM P-TEFb Complex Subunit 1) is a Protein Coding gene. Diseases associated with HEXIM1 include Nut Midline Carcinoma and Immune Deficiency Disease. Among its related pathways are Initiation of transcription and translation elongation at the HIV-1 LTR and Chromatin Regulation / Acetylation.

"Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors". Cancer Res. 63 (16): 5151–8.

Hexim1 acts as a tumor suppressor and is involved in the regulation of innate immunity. It was initially described as a non-coding RNA-dependent regulator of transcription. Here, we detail how 7SK RNA binds to Hexim1 and turns it into an inhibitor ...

Aug 3, 2017 · HEXIM1 and the NEAT1 long non-coding RNA form a platform to assemble the rest of the complex, including components of the DNAPK-cGAS-TBK1-IRF3 signaling cascade. Silencing either HEXIM1 or NEAT1 disrupts the HDP-RNP complex and decreases cytosolic DNA-dependent IFN production.

Dec 21, 2023 · HEXIM1 regulates erythroid proliferation and fetal globin expression in a positive transcription factor β–dependent manner. GATA1 co-occupancy determines whether HEXIM1 functions as an activator or a repressor at specific loci.

Feb 8, 2025 · HEXIM1 is an essential transcription regulator during human erythropoiesis. UHRF1 Suppresses HIV-1 Transcription and Promotes HIV-1 Latency by Competing with p-TEFb for Ubiquitination-Proteasomal Degradation of Tat. Downregulation of Dihydrotestosterone and Estradiol Levels by HEXIM1.

Hexamethylene bisacetamide-inducible protein 1 (HEXIM1) is best known as the inhibitor of positive transcription elongation factor b (P-TEFb), which regulates the transcription elongation of RNA polymerase II and controls 60–70% of mRNA synthesis.