对差异基因进行 go分析 ，结果表明，hfd vs ncd组差异基因主要与类固醇代谢过程、脂质生物合成过程的调节和脂质代谢过程相关；hgh vs hfd组差异基因主要与昼夜节律调节、能量储备代谢过程、fa（脂肪酸）代谢过程相关；ncd vs ngh组差异基因主要与脂质生物合成和 ...

2022年6月17日 · Compared with NCD, HFD feeding could significantly promote the transcription levels of TNFα, IL1β, and IL6, while decrease the transcription levels of IL4 and IL10, indicating the inflammatory responses were activated by HFD in white adipose tissue.

2021年8月11日 · 为了解决疑问，研究者们以正常饮食（NCD）和高脂饮食(HFD)分别喂养小鼠2-16周，流式检测VAT-Treg变化，发现NCD小鼠VAT-Treg升高，而HFD小鼠VAT-Treg在2-4周先升高，而在8-16周后却急剧降低。

2 天之前 · The HFD group exhibited increased Tnfa expression relative to the NCD group, alongside a significant decrease in Il25 mRNA expression, whereas Tslp and Il33 levels were unchanged (Fig. 3A). We ...

2025年3月4日 · Here, we show that ferroptotic signaling elicited by ferroptosis agonists reduces fat accumulation in primary adipocytes and in high-fat diet (HFD)-fed mice. Moreover, we found that both ACSL4 and FTH regulate ferroptotic signaling and adipose expansion in HFD-fed mice.

2025年3月20日 · In the HFD groups, the NCD was replaced with a 60% HFD. During the 4-week HFD exposure, the mice received intravenous administration of EVs derived from either young or middle-aged adipose ...

2024年7月24日 · As a model, a high-fat diet (HFD) induces obesity and steatosis in mice. In response to an HFD, the BA synthesis becomes dysregulated 16. Nfil3 expression is elevated in patients with liver...

2024年5月9日 · 本研究采用单细胞rna测序研究正常饲喂（ncd）的对照小鼠和高脂肪饮食诱导（hfd）的肥胖小鼠骨髓单细胞图谱及转录组的差异。 基于scRNA-seq探究HFD诱导过程中组织分泌GCA的细胞 ，找到了中性粒细胞为表达该基因的主要细胞群，并通过单细胞测序着重描绘了骨髓 ...

4 天之前 · To study the effect of HFD on HCC development, mice were injected intraperitoneally with DEN 14 days after birth, then were fed with normal chow diet (NCD) or HFD until sacrifice at age of 40 weeks. The results suggested that HFD …

2 天之前 · The effects of bromocriptine against hepatic ER stress were investigated according to previous studies [34,35], as follows: C57BL/6J mice (7–8 weeks old) were fed HFD or NCD for 8 weeks, and bromocriptine (10 mg/kg, i.p.) or vehicle (10% ethanol, i.p.) was then administered daily at ZT14 for 2 weeks under random fed conditions, except on the ...