2001年1月15日 · We now report that HGF induces directional migration and cytokine secretion in human monocytes. Monocyte activation by endotoxin and IL-1β results in the up-regulation of the HGF receptor expression and in the induction of cell-associated pro-HGF convertase activity, thus enhancing cell responsiveness to the factor.

Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

2024年4月18日 · 肝细胞生长因子（HGF），这个看似低调的名称背后隐藏着令人惊叹的生命调控力量。 作为旁分泌性细胞生长、运动和形态发生的重要驱动力，HGF是由间充质细胞精心培育的多功能细胞信号使者，对上皮来源细胞的生长、发育与再生起着关键作用。 HGF的独特之处在于其单链结构，它由29个氨基酸构成的信号序列和前体序列共同组成，延伸出728个氨基酸残基的前肽。 这一精密设计使得HGF能够精准地与细胞表面的c-Met原癌基因受体结合，触发一条深藏不露 …

2015年4月1日 · In this review, we discuss the actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases. 1. Introduction. Hepatocyte growth factor (HGF), also called scatter factor, is a polypeptide growth factor that belongs to the plasminogen family.

2010年8月2日 · Hepatocyte growth factor (HGF) and scatter factor (SF) were discovered independently for their abilities to induce the proliferation of primary hepatocytes and dissociation/motility of epithelial cells (scattering), respectively. After biochemical purification and cDNA cloning, the two proteins were shown to be the same molecule.

Hepatocyte growth factor (HGF), also known as scatter factor (SF), is a pleotropic factor required for normal organ development during embryogenesis. In the adult, basal expression of HGF maintains tissue homeostasis and is up-regulated in response to tissue injury.

Hepatocyte growth factor (HGF) is a pleiotropic cytokine composed of an α-chain and a β-chain, and these chains contain four kringle domains and a serine protease-like structure, respectively. The receptor for HGF was identified as the c-met proto-oncogene product of transmembrane receptor tyrosine kinase.

2020年11月18日 · HGF is a multifunctional growth factor that, like its specific receptor c-Met, is widely expressed in several bone and joint tissues. HGF has profound effects on cell survival and proliferation, matrix metabolism, inflammatory response, and neurotrophic action. HGF plays an important role in normal bone and cartilage turnover.

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases.

HGF activator (HGFAC) is a serum activator of proHGF and produces robust HGF activities in injured tissues. HGFAC is a coagulation factor XII-like serine endopeptidase that circulates in the plasma as a zymogen (proHGFAC). Thrombin, kallikrein-related peptidase (KLK)-4 or KLK-5 efficiently activates proHGFAC.