该团队确定了肝类器官各分化阶段所必须的四种生长因子，包括Activin A、BMP4、OSM和HGF。 研究发现，HGF对温度诱导的降解高度敏感，这可能导致其在培养过程中的活性降低，因此需要额外加入胎牛血清增强稳定性。 此外，HGF需要为大量细胞的高密度分化提供足量信号，因此其浓度也是类器官培养效果的重要影响因子，需要通过精确调控HGF的浓度来满足肝类器官分化的需求。 图3：hiPSC衍生的肝类器官（HLO）的形态. 非酒精性脂肪性肝病（NAFLD）是全球最常见 …

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Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

2024年4月18日 · 作为旁分泌性细胞生长、运动和形态发生的重要驱动力，HGF是由间充质细胞精心培育的多功能细胞信号使者，对上皮来源细胞的生长、发育与再生起着关键作用。 HGF的独特之处在于其单链结构，它由29个氨基酸构成的信号序列和前体序列共同组成，延伸出728个氨基酸残基的前肽。 这一精密设计使得HGF能够精准地与细胞表面的c-Met原癌基因受体结合，触发一条深藏不露的酪氨酸激酶信号通路，掌控着细胞的生命进程，包括生长的启动、运动的调控以及形 …

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Hepatocyte growth factor (HGF) is a pleiotropic cytokine composed of an α-chain and a β-chain, and these chains contain four kringle domains and a serine protease-like structure, respectively. The receptor for HGF was identified as the c-met proto-oncogene product of transmembrane receptor tyrosine kinase.

Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases.

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HGF（Human growth factor）即人类生长因子。 随着基因科学的发展，科学家们成功地从植物中提取生长因子。 它是一种 生物活性肽 复合物，有多个特殊氨基酸组成肽链，进入人体血液后，促进我们的 下丘脑 自行分泌人体生长素，而人体生长素对我们的生长发育、各种蛋白质的合成、细胞的修复和分裂繁殖、 激发胸腺恢复功能，增强人体免疫力、促进新陈代谢、增强人体排毒功能、再造老器官功能、抗击衰老、整体增进健康水平有着决定性的作用。 生长因子作为特殊的氨 …